about
sameAs
P688
Functional and physical interaction between WRN helicase and human replication protein AKu complex interacts with and stimulates the Werner proteinPotent inhibition of werner and bloom helicases by DNA minor groove binding drugsCharacterization of the human and mouse WRN 3'-->5' exonucleaseDiverged nuclear localization of Werner helicase in human and mouse cellsThe Bloom's and Werner's syndrome proteins are DNA structure-specific helicasesTelomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicasesPromyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in γ-irradiation-induced DNA damage responsesWerner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosomeRegulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylationWRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shorteningWerner syndrome protein interacts functionally with translesion DNA polymerasesThe Werner syndrome protein is a DNA helicaseAsymmetry of DNA replication fork progression in Werner's syndromeThe human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1The Werner and Bloom syndrome proteins catalyze regression of a model replication forkEffect of age and apoptosis on the mouse homologue of the huWRN geneWRN exonuclease structure and molecular mechanism imply an editing role in DNA end processingWerner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distributionNucleolar localization of the Werner syndrome protein in human cellsThe spectrum of WRN mutations in Werner syndrome patientsPhysical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factorsThe Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1WRN translocation from nucleolus to nucleoplasm is regulated by SIRT1 and required for DNA repair and the development of chemoresistanceThe DNA structure and sequence preferences of WRN underlie its function in telomeric recombination eventsRECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenanceInhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands
P921
Q22010009-10AF9E1E-61A8-4ACC-B1A5-E81AB0647CA5Q22253994-75FC10A3-F29A-4DE4-9EB2-56CA7537BC0AQ22254376-7F20646E-CD88-455F-BEEA-19C710ABA9A1Q22254412-CCA6D316-AD94-468F-995F-DD709DCCD59AQ24291356-2FA2344C-B980-4069-9573-A08FE2AB634DQ24291390-D09132D4-AB9A-489B-A498-67D574A2713BQ24304488-4A69F1FD-5766-4750-91C4-0EBFDE6FC702Q24305398-D210024D-A224-4A0D-8ADB-F855F9DCB4E3Q24305438-D469802E-DAC8-465B-926C-C3CD5A413563Q24306868-32DDCCA9-2F37-457C-97A4-3B3EA4F1812EQ24307499-E8E61E35-734C-46AD-82DE-7C14946EAC08Q24309639-37A76942-BE93-4D4E-9B74-B4CA73D07184Q24310486-4D76FF5B-50AE-4237-915D-A50A2F8724C1Q24311409-484DD36B-A20B-4501-B0C5-0589E9706C17Q24316909-4D53FF05-3858-4AD3-B9F8-0E0CD37DCF00Q24317819-E3C6441D-51C7-4ACF-BA38-FC4D2DBA7606Q24318413-BFC62957-07ED-49A4-B408-8567E87E3DF8Q24318651-79914C5A-1898-4D3F-8CF6-D907F37ED496Q24318820-4C0FC361-84F9-463A-802C-8A7A03F3E8B9Q24323083-504E2A60-EE1D-446A-A2D4-07E78174C8B7Q24324195-696535E6-53DA-478C-A408-A4167F826B33Q24338232-E409FF98-EC2D-4EEE-9C5A-D38A422FC8D6Q28116237-D80BEF50-B87F-445D-9CD6-F79B4451AD5AQ28116259-233D5679-B06F-4705-A37B-414F9A294974Q28259337-82FA908D-4D1A-4655-8DA9-7FA29D5F8700Q28596586-5D53D48A-3B5E-433E-94C7-247D596E9A77Q28771762-D71C6A3F-8857-4BD5-9879-D9D6FCE4192CQ28854554-4DC67B7C-576B-453D-857E-1F1E52F5EF35
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Werner syndrome RecQ like helicase
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
WRN
@es
WRN
@sh
WRN
@sr
WRN
@sr-el
Werner syndrome RecQ like helicase
@en
Werner syndrome RecQ like helicase
@nl
WРН
@sr-ec
type
label
WRN
@es
WRN
@sh
WRN
@sr
WRN
@sr-el
Werner syndrome RecQ like helicase
@en
Werner syndrome RecQ like helicase
@nl
WРН
@sr-ec
altLabel
3.1.-.-
@en
ATP-zavisna helikaza Vernerovog sindroma
@sr
DNA helicase, RecQ-like type 3
@en
RECQ3
@sr
RECQL2
@sr
RECQL3
@sr
RecQ3
@en
Vernerov sindrom, ATP zavisna helikaza
@sr
Vernerov sindrom, ATP-zavisna helikaza
@sr
WRN
@en
prefLabel
WRN
@es
WRN
@sh
WRN
@sr
WRN
@sr-el
Werner syndrome RecQ like helicase
@en
Werner syndrome RecQ like helicase
@nl
WРН
@sr-ec
P361
P527
P637
P638
P680
P681
P682
P352
P486
P31
P352
P361
P373
Werner syndrome ATP-dependent helicase, WRN
P486
D000071657
P527
P591
P637
XP_011542941
XP_011542942
XP_024303033
P638
P680
P681
P682
P702
P703
P705
ENSP00000298139