Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist
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Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia CellsRegulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling.MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse modelTargeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical TrialsToward a systems-level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile.Hedgehog Controls Quiescence and Activation of Neural Stem Cells in the Adult Ventricular-Subventricular Zone.Genetic activation of Hedgehog signaling unbalances the rate of neural stem cell renewal by increasing symmetric divisions.Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria.Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor.[Structure of the Smoothened receptor].
P2860
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P2860
Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist
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2011 nî lūn-bûn
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2011 թուականի Մարտին հրատարակուած գիտական յօդուած
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2011 թվականի մարտին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
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2011年論文
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2011年论文
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name
Identification and mechanism o ...... l potent Smoothened antagonist
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Identification and mechanism o ...... l potent Smoothened antagonist
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Identification and mechanism o ...... l potent Smoothened antagonist
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Identification and mechanism o ...... l potent Smoothened antagonist
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Identification and mechanism o ...... l potent Smoothened antagonist
@ast
Identification and mechanism o ...... l potent Smoothened antagonist
@en
Identification and mechanism o ...... l potent Smoothened antagonist
@en-gb
Identification and mechanism o ...... l potent Smoothened antagonist
@nl
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Identification and mechanism o ...... l potent Smoothened antagonist
@ast
Identification and mechanism o ...... l potent Smoothened antagonist
@en
Identification and mechanism o ...... l potent Smoothened antagonist
@en-gb
Identification and mechanism o ...... l potent Smoothened antagonist
@nl
P2093
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P3181
P356
P1476
Identification and mechanism o ...... l potent Smoothened antagonist
@en
P2093
Andre Mann
Angele Schoenfelder
Antonio Solinas
Elisabeth Traiffort
Fabrizio Manetti
Helene Faure
Hermine Roudaut
Ludwig Vincent
Martial Ruat
Maurizio Taddei
P304
P3181
P356
10.1124/MOL.110.069708
P407
P577
2011-03-01T00:00:00Z