Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.

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Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma.

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Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.

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http://www.wikidata.org/entity/Q47320107

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

@zh-cn

2017年学术文章

@zh-hans

2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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name

Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.

@en

Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.

@nl

type

Item

label

Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.

@en

Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.

@nl

prefLabel

Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.

@en

Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.

@nl

P1476

Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.

@en

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Barbara Marzocchi

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Giulia Bernardini

http://www.w3.org/2001/XMLSchema#string

Marcella Laschi

http://www.w3.org/2001/XMLSchema#string

Maurizio Orlandini

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Maurizio Taddei

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Silvia Gambassi

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P2860

Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist

Osteosarcoma: Current Treatment and a Collaborative Pathway to Success

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

A simple high-content cell cycle assay reveals frequent discrepancies between cell number and ATP and MTS proliferation assays

Developmental roles and clinical significance of hedgehog signaling

Hedgehog: functions and mechanisms

Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells.

Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: a non-randomised phase 2 clinical trial.

Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy.

Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists.

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4961-4971

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scholarly article

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10.1002/JCP.26330

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233

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2017-12-07T00:00:00Z

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29215700

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Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.

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P2860

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Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma.

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P1433

P1476

P2093

P2860

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P698

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P1476

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P698