Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
about
Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activityThe role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implicationsCullin family proteins and tumorigenesis: genetic association and molecular mechanismsDistinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4BDeregulation of F-box proteins and its consequence on cancer development, progression and metastasis.CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1Regulation of c-Myc Protein Abundance by a Protein Phosphatase 2A-Glycogen Synthase Kinase 3β-Negative Feedback Pathway.Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells.Human Sarcoma growth is sensitive to small-molecule mediated AXIN stabilization.Cellular senescence and protein degradation: breaking down cancerMYC cofactors: molecular switches controlling diverse biological outcomes.Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesisTranscriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2).PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cellsRegulation of c-Myc protein stability by proteasome activator REGγPathogenic Role of the CRL4 Ubiquitin Ligase in Human DiseaseCharacterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms.Targeting c-MYC in Platinum-Resistant Ovarian CancerE3 Ubiquitin Ligase RLIM Negatively Regulates c-Myc Transcriptional Activity and Restrains Cell ProliferationThe G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2.A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity.CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer.Aiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cellsMYC degradation under low O2 tension promotes survival by evading hypoxia-induced cell death.HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma.CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseasesOncoprotein stabilization in brain tumors.MYC degradationPost-translational control of Myc function during differentiation.Lysine-52 stabilizes the MYC oncoprotein through an SCF(Fbxw7)-independent mechanism.Deubiquitinating c-Myc: USP36 steps up in the nucleolus.Guard the guardian: A CRL4 ligase stands watch over histone production.The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity.The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity.The transcriptional landscape of αβ T cell differentiation.Hepatitis B virus X protein enhances Myc stability by inhibiting SCF(Skp2) ubiquitin E3 ligase-mediated Myc ubiquitination and contributes to oncogenesis.The ubiquitin-proteasome pathway in adult and pediatric brain tumors: biological insights and therapeutic opportunities.A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase.Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.Identification of a tumor suppressor network in T-cell leukemia.
P2860
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P2860
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
@ast
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
@en
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
@en-gb
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
@nl
type
label
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
@ast
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
@en
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
@en-gb
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
@nl
prefLabel
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
@ast
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
@en
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
@en-gb
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
@nl
P2093
P2860
P3181
P356
P1433
P1476
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells
@en
P2093
Jason B Wright
Michael D Cole
Seung H Choi
P2860
P304
P3181
P356
10.1101/GAD.1920310
P407
P577
2010-06-01T00:00:00Z