A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
about
Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complexThe human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiationHuman DNA damage checkpoint protein hRAD9 is a 3' to 5' exonucleasec-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damageA human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonucleaseIdentification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint geneReconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNAHuman and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosisHus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damageAnalysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control geneA CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damageHuman checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cellsThe novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p.Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damageHuman homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosisPCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibitionReconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complexA role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complexp53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaksSum1, a highly conserved WD-repeat protein, suppresses S-M checkpoint mutants and inhibits the osmotic stress cell cycle response in fission yeastLocalization of hRad9 in breast cancer.hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation.ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation.Structure-function analysis of fission yeast Hus1-Rad1-Rad9 checkpoint complexBH3-only proteins in apoptosis and beyond: an overview.DNA damage-dependent and -independent phosphorylation of the hRad9 checkpoint protein.Phosphorylation of Rad9 at serine 328 by cyclin A-Cdk2 triggers apoptosis via interfering Bcl-xLHuman RAD9 checkpoint control/proapoptotic protein can activate transcription of p21.Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit.XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus.Combined haploinsufficiency and genetic control of the G2/M checkpoint in irradiated cells.Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations.Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiationRecruitment of the Rad9-Hus1-Rad1 complex to DNATelomeres, histone code, and DNA damage response.Over expression of hRad9 protein correlates with reduced chemosensitivity in breast cancer with administration of neoadjuvant chemotherapy.Robust gene expression changes in the ganglia following subclinical reactivation in rhesus macaques infected with simian varicella virus.
P2860
Q22008596-3E53BDF4-C48F-4265-8E6B-01E9604BC88BQ22009947-ED1E219E-0649-48A0-BBA2-85F780624130Q22010921-13EC420C-BA22-4AFD-94D4-B9EE5226DF09Q22253323-B6D3CC46-B150-43D5-9561-72CA248F2D1FQ24295019-0D139F7E-45F0-427E-9F4D-CC61F4ECFA56Q24314103-815FB7BD-F4AD-4CBA-82F1-EC9AD5C3A24EQ24314250-2A81CE93-C46F-4BF4-9D48-3CBC4030A56EQ24322818-85E242EC-2D67-4D8B-A527-2A49000257A8Q24336800-71C9E3B5-5D15-49A7-8F9C-92F6073C7D4AQ24533206-210ED103-72AF-430E-AA30-0C501200D003Q24533460-5609088D-FAF0-43A0-B4BD-D9285555FE02Q24548232-EF5578A4-6E95-40B3-9552-4E982FCB42F6Q24554315-AAA76946-7D30-4666-B208-BDB7B0886089Q24607572-48E75E2F-4945-494A-99D7-98E1B7CFD6EBQ27931266-2361069A-D1BC-4091-9686-5CF2D11DD904Q27933181-09ED3CA9-A67B-4929-AB7C-0D9848E1F270Q28138254-B8A6A71D-781E-45C5-AC58-7E4E398AA3D5Q28141886-6F726513-6C56-44BF-A461-7B7D0AAB74DEQ28143834-C4931446-D633-44C1-B2E8-3B1BEE1B763EQ28187599-2C8A6D4F-B71C-4AFD-886E-404E3C2C7EFDQ28216748-B824C08E-016C-489E-A7FB-5E14D042C6D5Q30014828-20F9A16B-900C-4937-BA64-F664D8F79554Q32066415-2037396D-82DD-4786-A2C1-C921E5113C65Q33350703-7868E85D-09F6-4CC3-9DFE-5D86403984DCQ33859113-74F43BAF-9F0D-4208-A065-BDA9D39DEAF8Q33940379-8A75C65A-FDD5-44F4-96CF-D3C81AA69367Q33948751-F9315C1F-158B-424A-A88F-1280971ACF9AQ34085370-896C30A8-A633-4E25-8771-25DBB0005BE8Q34090839-0A70B0CD-B4D7-4B29-BA95-3EA61B34450AQ34427671-D12D665C-D4A8-43BD-9DD5-60C223A52374Q34828045-73AF2073-9833-4E69-A7AC-A30D79F4C10DQ35078637-CC8DA85C-CD4A-4FAD-B128-A16E86EB265DQ35973773-1E9A6676-FA49-4D4D-9ED1-2CDC97EBCFE9Q36107116-0DBAF1AF-003B-47D8-9400-0FED45B8DA49Q36359653-FDFCD8F3-B713-40D4-9AE2-BB17666DA51BQ36571200-AFCE65A2-FE47-48D2-9FB5-D2122E61F7BDQ36813085-33079897-3528-4B61-BEA9-7CF012EA6D72Q37384129-6B1625E0-BE3E-4110-B6AB-6B10A3FABF03Q37736274-90442903-E52C-49D8-98A7-25F1BA224ED5Q38435706-EA285C6A-5FC0-42C7-939A-3B9F19A12109
P2860
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
description
1996 nî lūn-bûn
@nan
1996 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
@ast
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
@en
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
@en-gb
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
@nl
type
label
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
@ast
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
@en
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
@en-gb
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
@nl
prefLabel
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
@ast
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
@en
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
@en-gb
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
@nl
P2093
P2860
P356
P1476
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.24.13890
P407
P577
1996-11-26T00:00:00Z