Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
about
Combined RNAi-mediated suppression of Rictor and EGFR resulted in complete tumor regression in an orthotopic glioblastoma tumor modelActive-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptideSREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growthmTORC2 phosphorylates protein kinase Cζ to regulate its stability and activityPRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12Protein kinases and phosphatases in the control of cell fateFat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolismSpatial regulation of the mTORC1 system in amino acids sensing pathwayTargeting mTOR for the treatment of AML. New agents and new directionsThe substrates and binding partners of protein kinase CepsilonPushing the envelope in the mTOR pathway: the second generation of inhibitorsRegulation of protein kinase C inactivation by Fas-associated protein with death domainMammalian target of rapamycin (mTOR): conducting the cellular signaling symphonyTargeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapymTOR: from growth signal integration to cancer, diabetes and ageingCharacterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1A complex interplay between Akt, TSC2 and the two mTOR complexesmTOR complex 2 is required for the development of prostate cancer induced by Pten loss in miceSirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular EffectsInhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and BeyondTargeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?Biochemical Genetic Pathways that Modulate Aging in Multiple SpeciesDual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal CancersDynamics and Membrane Interactions of Protein Kinase CThe PI3K/AKT Pathway and Renal Cell CarcinomaMolecular characterizations of glioblastoma, targeted therapy, and clinical results to dateThe atypical PKCs in inflammation: NF-κB and beyondmTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic InterventionsEmerging role of protein kinase C in energy homeostasis: A brief overviewThe Novel PKCθ from Benchtop to ClinicEndothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult.mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling AxisRictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progressionCrystal Structure and Allosteric Activation of Protein Kinase C βIIProtein kinase C mechanisms that contribute to cardiac remodellingDepletion of Rictor, an essential protein component of mTORC2, decreases male lifespanRegulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networksProtein kinase C: poised to signal
P2860
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P2860
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Essential function of TORC2 in ...... ion, maturation and signalling
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Essential function of TORC2 in ...... ion, maturation and signalling
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Essential function of TORC2 in ...... ion, maturation and signalling
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Essential function of TORC2 in ...... ion, maturation and signalling
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type
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Essential function of TORC2 in ...... ion, maturation and signalling
@ast
Essential function of TORC2 in ...... ion, maturation and signalling
@en
Essential function of TORC2 in ...... ion, maturation and signalling
@en-gb
Essential function of TORC2 in ...... ion, maturation and signalling
@nl
prefLabel
Essential function of TORC2 in ...... ion, maturation and signalling
@ast
Essential function of TORC2 in ...... ion, maturation and signalling
@en
Essential function of TORC2 in ...... ion, maturation and signalling
@en-gb
Essential function of TORC2 in ...... ion, maturation and signalling
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P2093
P2860
P3181
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Essential function of TORC2 in ...... ion, maturation and signalling
@en
P2093
Kun-Liang Guan
Tsuneo Ikenoue
Xiaoming Zhou
P2860
P304
P3181
P356
10.1038/EMBOJ.2008.119
P407
P577
2008-07-23T00:00:00Z