Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
about
Identification of Protor as a novel Rictor-binding component of mTOR complex-2The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathwayDNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survivalClipR-59 interacts with Akt and regulates Akt cellular compartmentalizationEssential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signallingPRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12Spatial regulation of the mTORC1 system in amino acids sensing pathwayAn emerging role for TOR signaling in mammalian tissue and stem cell physiologyTargeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapyTti1 and Tel2 are critical factors in mammalian target of rapamycin complex assemblymTOR: from growth signal integration to cancer, diabetes and ageingFeature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiologymTOR signaling in growth control and diseaseCharacterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1mTOR signaling: at the crossroads of plasticity, memory and diseasePotential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathwayRegulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylationmTOR complex 2 is required for the development of prostate cancer induced by Pten loss in miceTargeting the mTOR signaling network for cancer therapyThe role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistanceLive strong and prosper: the importance of skeletal muscle strength for healthy ageingmTOR-dependent cell survival mechanismsShedding new light on neurodegenerative diseases through the mammalian target of rapamycinNutrient regulation of the mTOR complex 1 signaling pathwayThe TORC2 component, Sin1, controls migration of anterior mesendoderm during zebrafish gastrulationTor forms a dimer through an N-terminal helical solenoid with a complex topology.Gammadelta T cells are reduced and rendered unresponsive by hyperglycemia and chronic TNFalpha in mouse models of obesity and metabolic diseaseUtilization of paramagnetic relaxation enhancements for high-resolution NMR structure determination of a soluble loop-rich protein with sparse NOE distance restraintsArchitecture of human mTOR complex 1Rag proteins regulate amino-acid-induced mTORC1 signalling.Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2.Left-right asymmetry in the light of TOR: An update on what we know so farmTOR signaling in tumorigenesisBSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiationRictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell sizeNovel binding partners and differentially regulated phosphorylation sites clarify Eps8 as a multi-functional adaptorProtor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidneyThe mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase CMultiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein.Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins
P2860
Q24303936-C24F25D2-D9CE-4D1E-9B67-8290E69765B1Q24312720-80B435F3-D038-4225-8A8F-759F54CAE794Q24316008-B7B43C0F-A4C8-40EC-B07B-820A04C2F70CQ24316193-32512DE2-15B4-4D44-964F-F6D68C7FD9EBQ24323370-B1B1DBEA-2076-46DD-A00D-45A934A1487AQ24323912-936D693A-9AA7-4F26-BD79-9DE44C81AB48Q24612853-F46DB0B5-A879-49F8-9031-4EF8A93A08D4Q24629305-2E929A6F-808E-4A1C-AFD9-68E1FD7D8BD9Q24632296-8624E7C0-EEFD-4583-8392-CF40F30C0E35Q24632884-ED9B8F76-49AB-4F0D-8DAA-4B7EDFC7E67BQ24633662-2931F444-A387-4CF2-87D4-DB9AAF765869Q24634012-6BAEA67D-93B6-4747-8AA9-10ACB1156F25Q24634174-F725FBA2-DA05-41D4-9A78-F8287D6BAA40Q24645183-4FF8C381-F205-4936-AC14-551A4C854892Q24647655-36061C64-E6E5-4D36-8AA1-00556C14F806Q24648029-7C4F35CB-1FC7-4A3F-84C4-E8B47AB9FB2FQ24648213-1118E05B-221F-4F6C-B5F8-EF3EECC41D8CQ24658113-42BA45BD-77B9-4709-B82E-8E9E6A58F332Q24658334-3CC81A4D-CF4B-41F1-91F7-F5A565D43222Q26741046-FB2D0D7B-E27C-491B-B8A8-862A1B5C1849Q26770637-719F691B-CEC8-4315-851C-1B252F3BBC3AQ26864688-BCAA1186-427A-4E90-B30C-5C016B2BE08BQ27015640-0962C881-4092-451B-AB5E-E5248301225DQ27027823-2486EA67-C659-4363-A819-A86DD2FD436CQ27313929-CD39AD9F-DCE7-4F22-B363-6599BAD0BEBDQ27323551-8EE5141B-8A64-4AFE-AFA1-FE7F688661B7Q27324312-6B2CB34B-AC65-4575-AC69-C9336A2FF365Q27696218-3463C351-D2C3-47C4-B833-F5447AE57BAEQ27703146-41C9C045-15E7-4354-8C0F-355700AE190AQ27863397-4A374832-CD47-4655-BE45-9E32DD74C46FQ27933222-EE488EE5-A912-4C2E-AE3D-218620FBF0E9Q28080826-D2D8569E-A9D3-4691-89F6-444EC44601C9Q28252695-EF5FBA1A-C0B9-421E-9F68-9D953937D3F7Q28282926-64486C3B-391F-4817-98BD-049D9103CB7CQ28304000-894B9748-30AF-469F-8848-798667E809CCQ28486658-B048C174-4DD5-4557-A1CD-F04E1B8B7872Q28507177-377FC2B3-BC49-4FE5-9597-1D8B4B6F92CCQ28587901-3D648329-2718-46F1-8BF0-FA21F1B89CA4Q30423008-226DF9AF-4CA1-4FCB-BB38-7EEA2D50CABFQ30438876-ED197714-DD63-4C66-97D9-CF624BD284F9
P2860
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Identification of Sin1 as an e ...... formation and kinase activity
@ast
Identification of Sin1 as an e ...... formation and kinase activity
@en
Identification of Sin1 as an e ...... formation and kinase activity
@nl
type
label
Identification of Sin1 as an e ...... formation and kinase activity
@ast
Identification of Sin1 as an e ...... formation and kinase activity
@en
Identification of Sin1 as an e ...... formation and kinase activity
@nl
prefLabel
Identification of Sin1 as an e ...... formation and kinase activity
@ast
Identification of Sin1 as an e ...... formation and kinase activity
@en
Identification of Sin1 as an e ...... formation and kinase activity
@nl
P2093
P2860
P3181
P356
P1433
P1476
Identification of Sin1 as an e ...... formation and kinase activity
@en
P2093
Kun-Liang Guan
Tsuneo Ikenoue
P2860
P304
P3181
P356
10.1101/GAD.1461206
P407
P577
2006-10-15T00:00:00Z