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The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

http://www.wikidata.org/entity/Q24324097

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Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.The effect of eukaryotic release factor depletion on translation termination in human cell lines SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeast An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2 Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor Splicing enhances translation in mammalian cells: an additional function of the exon junction complex Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway.Itt1p, a novel protein inhibiting translation termination in Saccharomyces cerevisiae Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems The dharma of nonsense-mediated mRNA decay in mammalian cells Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2 Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing.Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeast NMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae.Fine-tuning of translation termination efficiency in Saccharomyces cerevisiae involves two factors in close proximity to the exit tunnel of the ribosome.Tpa1p is part of an mRNP complex that influences translation termination, mRNA deadenylation, and mRNA turnover in Saccharomyces cerevisiae.Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay.Posttranscriptional control of gene expression in yeast.Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit.Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough.

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The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

http://www.wikidata.org/entity/Q24324097

description

1998 nî lūn-bûn

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1998 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի հունիսին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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The surveillance complex inter ...... ion and degrade aberrant mRNAs

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The surveillance complex inter ...... ion and degrade aberrant mRNAs

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The surveillance complex inter ...... ion and degrade aberrant mRNAs

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The surveillance complex inter ...... ion and degrade aberrant mRNAs

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The surveillance complex inter ...... ion and degrade aberrant mRNAs

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The surveillance complex inter ...... ion and degrade aberrant mRNAs

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The surveillance complex inter ...... ion and degrade aberrant mRNAs

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The surveillance complex inter ...... ion and degrade aberrant mRNAs

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prefLabel

The surveillance complex inter ...... ion and degrade aberrant mRNAs

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The surveillance complex inter ...... ion and degrade aberrant mRNAs

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The surveillance complex inter ...... ion and degrade aberrant mRNAs

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The surveillance complex inter ...... ion and degrade aberrant mRNAs

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Genes & Development

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The surveillance complex inter ...... ion and degrade aberrant mRNAs

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H A Perlick

http://www.w3.org/2001/XMLSchema#string

H C Dietz

http://www.w3.org/2001/XMLSchema#string

K Czaplinski

http://www.w3.org/2001/XMLSchema#string

M D Ter-Avanesyan

http://www.w3.org/2001/XMLSchema#string

M J Ruiz-Echevarria

http://www.w3.org/2001/XMLSchema#string

S V Paushkin

http://www.w3.org/2001/XMLSchema#string

S W Peltz

http://www.w3.org/2001/XMLSchema#string

X Han

http://www.w3.org/2001/XMLSchema#string

Y Weng

http://www.w3.org/2001/XMLSchema#string

P2860

A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor

Mammalian orthologues of a yeast regulator of nonsense transcript stability

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein

Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor

The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae

Interaction between yeast Sup45p (eRF1) and Sup35p (eRF3) polypeptide chain release factors: implications for prion-dependent regulation.

Relationship between yeast polyribosomes and Upf proteins required for nonsense mRNA decay.

Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover.

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.

The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm.

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1665-77

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scholarly article

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591876

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P356

10.1101/GAD.12.11.1665

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11

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12

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1998-06-01T00:00:00Z

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13663352

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P698

9620853

http://www.w3.org/2001/XMLSchema#string

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regulation of translational termination

UPF1 RNA helicase and ATPase

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316864

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