Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways - Wikidata - wikimedia - TriplyDB

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

http://www.wikidata.org/entity/Q24311680

about

Fuzziness: linking regulation to protein dynamics DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex Ago2/miRISC-mediated inhibition of CBP80/20-dependent translation and thereby abrogation of nonsense-mediated mRNA decay require the cap-associating activity of Ago2 SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2 NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon Ribosome-based quality control of mRNA and nascent peptides Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact Mechanism and regulation of the nonsense-mediated decay pathway Mechanisms of deadenylation-dependent decay The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover The dharma of nonsense-mediated mRNA decay in mammalian cells The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.Structural insights into eRF3 and stop codon recognition by eRF1 Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2 Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit.The DEAD-box protein Dhh1 promotes decapping by slowing ribosome movement Nonsense-mediated mRNA decay in humans at a glance Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story Translation initiation: variations in the mechanism can be anticipated Organizing principles of mammalian nonsense-mediated mRNA decay Mutations in SMG9, Encoding an Essential Component of Nonsense-Mediated Decay Machinery, Cause a Multiple Congenital Anomaly Syndrome in Humans and Mice Anti-PABPC1 co-immunoprecipitation for examining the miRNAs directly targeting the 3'-UTR of EED mRNA Eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay by two genetically separable mechanisms In Silico Analysis of the Structural and Biochemical Features of the NMD Factor UPF1 in Ustilago maydis The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins Inhibition of Nonsense-mediated mRNA Decay by the Natural Product Pateamine A through Eukaryotic Initiation Factor 4AIII Plakophilin-associated RNA-binding proteins in prostate cancer and their implications in tumor progression and metastasis.Large G3BP-induced granules trigger eIF2α phosphorylation.HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.Nucleosome deposition and DNA methylation may participate in the recognition of premature termination codon in nonsense-mediated mRNA decay.Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay.Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe Nonsense-mediated mRNA decay maintains translational fidelity by limiting magnesium uptake

P2860

a29933815e148b2bfcd5e28956915ad31d7c387c bad06dd122eda61d4387e4d8f79c8dcfd1204019 bcea264768ec10bc1ceb7de9518aaee7be5d4b62 cf9dda4c292726e36c6de64f0de768f23ee6d85b d7d6e86d5d4da5d3cac0068b1382d237e8f68501

P248

Q22061730-CEB65B57-9D45-4030-A60F-833B388FD917 Q24297565-D5BE4CB9-4BE0-4D83-A6E2-AA7281A90BE5 Q24298609-62D5150F-1FB1-42F1-A89E-1B5BD6FD7B00 Q24321947-9B7399BE-C337-46E3-9151-F7B1DEB6721F Q24322423-34EF4F48-76B3-47A1-95A2-7573D2934090 Q24336651-33BFCFB0-47E0-4ABE-9DEB-C963255660B9 Q24338494-CE0C5B6D-AC65-454D-BEED-FDDF60976064 Q24339439-195D445B-4492-44AE-93BB-129D50706B82 Q24602572-AF7B4886-841C-4140-B96E-26247979CE11 Q24613209-E5ED0471-1A10-4D21-9E7D-8979C1FCE644 Q26748589-F604456D-93C7-4F55-BD84-F075982F5477 Q26750271-33006B35-2C06-4533-9D01-B54DB12D5998 Q26771669-45D6B722-438B-4E87-983B-4A2FD3A5F551 Q26829435-953A4555-C1A2-45D1-AD8E-B58A9A0134F1 Q27010244-C501C5DC-F0BD-480B-BA82-E9C4B6CAB6BF Q27014757-079A5E6C-9F17-4045-A252-68BA7056E6BF Q27333986-75F12B5E-4087-49CF-91F2-5F56EF4DD605 Q27655386-2C241B28-E9F3-4AA7-8451-74A7AF37D715 Q27680677-D77D51B1-092A-40F1-9C00-09A9F69E2382 Q27938110-D507BE49-5C65-4BEE-AF3E-B2A5862E6273 Q27940178-B81CF292-EE3C-48B8-9853-A64ACF55BCB7 Q28077157-1D7B6889-A0BE-4EBD-BA1B-8FB0443371E2 Q28082699-2B9D3AD4-4FA4-44A7-AF62-CB881A658914 Q28298359-DE3D6852-01B2-4D23-BBDB-D4EB0E399EF8 Q28302705-2D1DAB27-A5AD-4856-A8E9-551AF7376272 Q28513439-BD3EE493-D6E2-43F5-8C38-3D989B7C34A2 Q28541520-EA1D2DCD-241C-4EE3-9628-AB9E0003FE59 Q28542512-800F5F89-CE64-4584-BBC4-82D9F2955B6D Q28550086-67E2510D-7B14-4469-8EA0-71D3EFDAA2C7 Q28596579-159CCF4F-CA58-4B44-AECC-F99FD96BA100 Q28910386-BAA4CB4C-7AD2-4B57-A04D-4D6CC2ACE95C Q29028235-4BE65984-798C-4937-98A3-4C502FD68D84 Q30009601-13F739CF-4C7D-4E18-9998-CAFB2C56AA93 Q30010041-05814B99-EA60-47E2-AFA1-28E4B0F50C39 Q30488459-1C23F0F2-5FFD-4642-8C5C-FAAD83CEA704 Q33455467-34243E51-627B-480E-9D6C-8F0371878A2E Q33646294-037E4CFF-5800-47C1-8E36-83FE8317681A Q33718674-189EC821-BC49-43DC-AFB8-E1DC1BA966FC Q33878474-90A8A8F3-6583-46AD-8D71-4A1547985CD4 Q33998863-C7EB8AF9-AFEC-4305-BBA5-F8273F42A5A4

P2860

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

http://www.wikidata.org/entity/Q24311680

description

2008 nî lūn-bûn

@nan

2008 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի մարտին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Interactions between UPF1, eRF ...... del for mammalian NMD pathways

@ast

Interactions between UPF1, eRF ...... del for mammalian NMD pathways

@en

Interactions between UPF1, eRF ...... del for mammalian NMD pathways

@en-gb

Interactions between UPF1, eRF ...... del for mammalian NMD pathways

@nl

type

label

Interactions between UPF1, eRF ...... del for mammalian NMD pathways

@ast

Interactions between UPF1, eRF ...... del for mammalian NMD pathways

@en

Interactions between UPF1, eRF ...... del for mammalian NMD pathways

@en-gb

Interactions between UPF1, eRF ...... del for mammalian NMD pathways

@nl

prefLabel

Interactions between UPF1, eRF ...... del for mammalian NMD pathways

@ast

Interactions between UPF1, eRF ...... del for mammalian NMD pathways

@en

Interactions between UPF1, eRF ...... del for mammalian NMD pathways

@en-gb

Interactions between UPF1, eRF ...... del for mammalian NMD pathways

@nl

P1433

Q24311680-7F0C9623-D83E-4D4A-ACA5-225441718776

P1476

Q24311680-75E7FA2D-0E1D-4C0F-881D-3060E08AF5D7

P2093

Q24311680-95A139DE-C96E-4AC2-9989-D94BF94ADBFD

Q24311680-C5C0A466-F04B-4D20-9AF4-9E273F501DF2

P2860

Q24311680-0A41C321-3A64-4914-82D2-C86EA55E2A4E

Q24311680-0B4836E3-7D72-49D8-90C9-378BDC9C3A87

Q24311680-0CAD5470-B2CF-4D31-B413-572B46BF688E

Q24311680-148745EF-FC91-4DE0-B460-09320F54368F

Q24311680-14AC7C78-C800-4BE7-B625-A9B31091AED9

Q24311680-151B791B-528F-4840-B91C-F02405690F6A

Q24311680-16D11749-1EEA-4B15-A8AA-5CF2140199F3

Q24311680-1DCF2FB7-6519-4A45-93B3-450A24D435DF

Q24311680-20D0C7D3-B661-4016-B927-4C577FE1D698

Q24311680-29AF567F-8949-4353-A305-8979A319DE38

P304

Q24311680-96292AA9-7294-4ED4-9C6C-033F300E8199

P31

Q24311680-88F51AE9-7760-409E-91FE-E75D8E6390D7

P3181

Q24311680-70F66FC8-EEBD-4F2C-8D53-4D1231CE9ABE

P356

Q24311680-0CE4ED63-45C5-43B4-AF38-7F996802DAFA

P407

Q24311680-0EBD4BAA-4629-4887-A243-7AEB969ECFE7

P433

Q24311680-B5F6825C-E843-4126-A588-20A1328985D4

P478

Q24311680-BBCC7AC9-7754-4C18-AFCE-FC05C8155BCC

P50

Q24311680-09B302A8-BE74-41D9-80A3-25702860EB2F

Q24311680-64EDDFEA-F2F7-4133-9DB3-2CDA3B76FEAF

Q24311680-E211A23A-D37B-4695-8C11-1A27E919F358

P577

Q24311680-1A3EA4D9-A3C3-4813-B5A9-D7FB4662EDBD

P698

Q24311680-3DFB9F3E-1A80-42CF-89F8-08108CECF02E

P932

Q24311680-26C7BE00-3146-4046-B1DF-72597B98184E

P3181

P356

P1433

The EMBO Journal

P1476

Interactions between UPF1, eRF ...... del for mammalian NMD pathways

@en

P2093

Andreas E Kulozik

http://www.w3.org/2001/XMLSchema#string

Joachim B Kunz

http://www.w3.org/2001/XMLSchema#string

P2860

Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm

Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex

Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1

Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

Y14 and hUpf3b form an NMD-activating complex

P304

736-47

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

591875

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/EMBOJ.2008.17

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

27

http://www.w3.org/2001/XMLSchema#string

P50

Niels H Gehring

Matthias Hentze

P577

2008-03-05T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

18256688

http://www.w3.org/2001/XMLSchema#string

P932

2265754

http://www.w3.org/2001/XMLSchema#string