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Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

http://www.wikidata.org/entity/Q26750271

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Exaptive origins of regulated mRNA decay in eukaryotes Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries Identification of a Novel Human E-Cadherin Splice Variant and Assessment of Its Effects Upon EMT-Related Events.Identification and molecular characterization of cellular factors required for glucocorticoid receptor-mediated mRNA decay Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways.Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay Aipl1 is required for cone photoreceptor function and survival through the stability of Pde6c and Gc3 in zebrafish.UPF1 helicase promotes TSN-mediated miRNA decay.The exon junction complex: a lifelong guardian of mRNA fate.mRNA localization as a rheostat to regulate subcellular gene expression.Control of gene expression through the nonsense-mediated RNA decay pathway.Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins.Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins.Translation initiation mediated by nuclear cap-binding protein complex.Nonsense-mediated mRNA decay at the crossroads of many cellular pathways Dual function of UPF3B in early and late translation termination.Optimized approach for the identification of highly efficient correctors of nonsense mutations in human diseases.RNA decay, evolution, and the testis.Conservation of Nonsense-Mediated mRNA Decay Complex Components Throughout Eukaryotic Evolution.Transport Granules Bound with Nuclear Cap Binding Protein and Exon Junction Complex Are Associated with Microtubules and Spatially Separated from eIF4E Granules and P Bodies in Human Neuronal Processes.Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.CRISPR-Trap: a clean approach for the generation of gene knockouts and gene replacements in human cells.HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition.Genotype-phenotype investigation of 35 patients from 11 unrelated families with camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome.Dissecting the functions of SMG5, SMG7 and PNRC2 in nonsense-mediated mRNA decay of human cells.Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations.An RNA decay factor wears a new coat: UPF3B modulates translation termination.Endoplasmic Reticulum Stress in Mice Increases Hepatic Expression of Genes Carrying a Premature Termination Codon via a Nutritional Status-Independent GRP78-Dependent Mechanism.Nonsense-mediated mRNA decay: a 'nonsense' pathway makes sense in stem cell biology.Csde1 binds transcripts involved in protein homeostasis and controls their expression in an erythroid cell line.Reactivation Assay to Identify Direct Targets of the Nonsense-Mediated mRNA Decay Pathway in Drosophila.Using Tet-Off Cells and RNAi Knockdown to Assay mRNA Decay.Hyperinsulinemia and Insulin Receptor Gene Mutation in Nonobese Healthy Subjects in Japan.Modulating the expression of Chtop, a versatile regulator of gene-specific transcription and mRNA export.Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis.ICE1 promotes the link between splicing and nonsense-mediated mRNA decay.ZFR coordinates crosstalk between RNA decay and transcription in innate immunity.Novel NTRK1 mutations in Chinese patients with congenital insensitivity to pain with anhidrosis.New insights into the interplay between the translation machinery and nonsense-mediated mRNA decay factors.Effect of BIS depletion on HSF1-dependent transcriptional activation in A549 non-small cell lung cancer cells.

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Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

http://www.wikidata.org/entity/Q26750271

description

2016 nî lūn-bûn

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2016 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2016 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2016年の論文

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2016年論文

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2016年論文

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2016年论文

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Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

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Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

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Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

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Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

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Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

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Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

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Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

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Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

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Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

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Wiley interdisciplinary reviews. RNA

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Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

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Evangelos D Karousis

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Oliver Mühlemann

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Sofia Nasif

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P2860

The RNA degradation pathway regulates the function of GAS5 a non-coding RNA in mammalian cells

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.

Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon

Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2

DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans

Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex

Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

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661-682

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10.1002/WRNA.1357

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303085989

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27173476

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