CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
about
Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylationInteraction of CTLA-4 with AP50, a clathrin-coated pit adaptor proteinCTLA-4 ligation blocks CD28-dependent T cell activationCD28 and CTLA-4 have opposing effects on the response of T cells to stimulationMultiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseasesUnifying concepts in CD28, ICOS and CTLA4 co-receptor signallingCD28 and CTLA-4 coreceptor expression and signal transductionCTLA-4 trafficking and surface expressionQuantitative analysis by surface plasmon resonance of CD28 interaction with cytoplasmic adaptor molecules Grb2, Gads and p85 PI3K.CTLA-4 activation of phosphatidylinositol 3-kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death.The role of CTLA-4 in the regulation of T cell immune responses.Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function.The B7/CD28/CTLA4 T-cell activation pathway. Implications for inflammatory lung disease.CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function.CD28, CTLA-4 and their ligands: who does what and to whom?Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tailA regulatory role for cytoplasmic YVKM motif in CTLA-4 inhibition of TCR signaling.T-cell regulation by CD28 and CTLA-4.CTLA-4 negative signaling via lipid rafts: A new perspective.CTLA-4: new insights into its biological function and use in tumor immunotherapy.Inhibitory Receptors Beyond T Cell Exhaustion.CTLA4 gene polymorphism and autoimmunity.Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation?Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activationCTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion.B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapyRegulation of T-cell responses by PTENIntrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 familyDiverse mechanisms regulate the surface expression of immunotherapeutic target ctla-4.CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function.Rab8 binding to immune cell-specific adaptor LAX facilitates formation of trans-Golgi network-proximal CTLA-4 vesicles for surface expression.T cells expressing constitutively active Akt resist multiple tumor-associated inhibitory mechanisms.Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4.CD28: a signalling perspective.The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response.The role of CTLA-4 in the regulation and initiation of T-cell responses.CTLA-4, a negative regulator of T-lymphocyte activation.Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.
P2860
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P2860
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
@ast
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
@en
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
@en-gb
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
@nl
type
label
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
@ast
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
@en
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
@en-gb
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
@nl
prefLabel
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
@ast
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
@en
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
@en-gb
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
@nl
P2093
P2860
P356
P1476
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
@en
P2093
H Schneider
K V Prasad
S E Shoelson
P2860
P356
10.1084/JEM.181.1.351
P407
P577
1995-01-01T00:00:00Z