Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.
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Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptorsMultiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseasesMultiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functionsUnifying concepts in CD28, ICOS and CTLA4 co-receptor signallingMolecular basis of T cell inactivation by CTLA-4PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit.Biochemical analysis of CTLA-4 immunoreactive material from human bloodThe role of CTLA-4 in the regulation of T cell immune responses.Checkpoint inhibitors in hematological malignanciesTyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function.Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4.Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells.Down-regulation of Th2 responses by Brucella abortus, a strong Th1 stimulus, correlates with alterations in the B7.2-CD28 pathwayInterleukin-4-independent acceleration of cutaneous leishmaniasis in susceptible BALB/c mice following treatment with anti-CTLA4 antibody.B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT ActivationLack of a role for transforming growth factor-beta in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation.Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tailActivation and inhibition of lymphocytes by costimulation.T-cell regulation by CD28 and CTLA-4.CTLA-4 negative signaling via lipid rafts: A new perspective.The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetesCostimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytes.The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits.Negative feedback of T cell activation through inhibitory adapters and costimulatory receptors.Viewpoint: therapeutic implications of CTLA-4 compartmentalization.c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity.Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activationNegative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.The role of E3 ubiquitin ligase Cbl proteins in interleukin-2-induced Jurkat T-cell activation.B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 familyConfusing signals: recent progress in CTLA-4 biologyImprinting of maternal thyroid hormones in the offspring.Chronic immune activation associated with intestinal helminth infections results in impaired signal transduction and anergyLack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.Flow cytometric analysis of immunoprecipitates: high-throughput analysis of protein phosphorylation and protein-protein interactions.The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.TCR subunit specificity of CTLA-4-mediated signaling.
P2860
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P2860
Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Cytotoxic T lymphocyte antigen ...... cell receptor zeta and ZAP70.
@en
type
label
Cytotoxic T lymphocyte antigen ...... cell receptor zeta and ZAP70.
@en
prefLabel
Cytotoxic T lymphocyte antigen ...... cell receptor zeta and ZAP70.
@en
P2093
P2860
P356
P1476
Cytotoxic T lymphocyte antigen ...... cell receptor zeta and ZAP70.
@en
P2093
P2860
P304
P356
10.1084/JEM.186.10.1645
P407
P577
1997-11-01T00:00:00Z