Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase
about
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extensionHuman JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factorPSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organizationProteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytesMRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrestScaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathwayA human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathwaysDirect activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivativeActivation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinaseCHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic responseHuman mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascadesMip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation.NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domainMEK kinases are regulated by EGF and selectively interact with Rac/Cdc42Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascadeSynergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activationRestoration of NF-kappaB activation by tumor necrosis factor alpha receptor complex-targeted MEKK3 in receptor-interacting protein-deficient cellsSignaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domainMEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cellsMolecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinaseA splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous systemThe mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activityMitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-betaMEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathwayMEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathwayTNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase relatedMEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinaseProtein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent mannerWNK1 activates ERK5 by an MEKK2/3-dependent mechanismMST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinaseMEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases14-3-3 proteins interact with specific MEK kinasesInduction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathwayThe MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinasesIdentification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase CCloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathwayActivation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metalsIdentification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways.Mekk3 is essential for early embryonic cardiovascular developmentExtracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures
P2860
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P2860
Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase
description
1996 nî lūn-bûn
@nan
1996 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մարտին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Molecular cloning of mitogen-a ...... rotein kinase and c-Jun kinase
@ast
Molecular cloning of mitogen-a ...... rotein kinase and c-Jun kinase
@en
Molecular cloning of mitogen-a ...... rotein kinase and c-Jun kinase
@en-gb
Molecular cloning of mitogen-a ...... rotein kinase and c-Jun kinase
@nl
type
label
Molecular cloning of mitogen-a ...... rotein kinase and c-Jun kinase
@ast
Molecular cloning of mitogen-a ...... rotein kinase and c-Jun kinase
@en
Molecular cloning of mitogen-a ...... rotein kinase and c-Jun kinase
@en-gb
Molecular cloning of mitogen-a ...... rotein kinase and c-Jun kinase
@nl
prefLabel
Molecular cloning of mitogen-a ...... rotein kinase and c-Jun kinase
@ast
Molecular cloning of mitogen-a ...... rotein kinase and c-Jun kinase
@en
Molecular cloning of mitogen-a ...... rotein kinase and c-Jun kinase
@en-gb
Molecular cloning of mitogen-a ...... rotein kinase and c-Jun kinase
@nl
P2093
P921
P356
P1476
Molecular cloning of mitogen-a ...... rotein kinase and c-Jun kinase
@en
P2093
P304
P356
10.1074/JBC.271.10.5361
P407
P577
1996-03-08T00:00:00Z