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WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

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Similar effects of all WNK3 variants on SLC12 cotransporters Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II WNK kinases, renal ion transport and hypertension WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells Neurotrophin-regulated signalling pathways WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension Calcium regulation of EGF-induced ERK5 activation: role of Lad1-MEKK2 interaction.Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR).Effect of renal lipid accumulation on proximal tubule Na+/H+ exchange and ammonium secretion.WNK1 activates SGK1 to regulate the epithelial sodium channel.Kinase mutations in human disease: interpreting genotype-phenotype relationships.Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling.A new methodology for quantification of alternatively spliced exons reveals a highly tissue-specific expression pattern of WNK1 isoforms.Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex.WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.WNK kinases influence TRPV4 channel function and localization.The WNKs: atypical protein kinases with pleiotropic actions.C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signaling Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling The role of specific mitogen-activated protein kinase signaling cascades in the regulation of steroidogenesis c-KIT signaling is targeted by pathogenic Yersinia to suppress the host immune response.Exome sequencing identifies a novel gene, WNK1, for susceptibility to pelvic organ prolapse (POP).WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism.Cardiovascular expression of the mouse WNK1 gene during development and adulthood revealed by a BAC reporter assay.WNK1 activates large-conductance Ca2+-activated K+ channels through modulation of ERK1/2 signaling.WNK1 promotes PIP₂ synthesis to coordinate growth factor and GPCR-Gq signaling Endothelial protective genes induced by statin are mimicked by ERK5 activation as triggered by a drug combination of FTI-277 and GGTI-298.Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts.The dynamic stress-induced "O-GlcNAc-ome" highlights functions for O-GlcNAc in regulating DNA damage/repair and other cellular pathways.WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway.Identification of Differentially Expressed Genes through Integrated Study of Alzheimer's Disease Affected Brain Regions Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension.Role of the WNK-activated SPAK kinase in regulating blood pressure.Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity

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WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

http://www.wikidata.org/entity/Q28234991

description

2004 nî lūn-bûn

@nan

2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի փետրվարին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

@ast

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

@en

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

@nl

type

label

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

@ast

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

@en

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

@nl

prefLabel

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

@ast

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

@en

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

@nl

P1433

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Journal of Biological Chemistry

P1476

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

@en

P2093

Bing-E Xu

http://www.w3.org/2001/XMLSchema#string

Byung-Hoon Lee

http://www.w3.org/2001/XMLSchema#string

Lisa Lenertz

http://www.w3.org/2001/XMLSchema#string

Melanie H Cobb

http://www.w3.org/2001/XMLSchema#string

Steve Stippec

http://www.w3.org/2001/XMLSchema#string

Wei Zhang

http://www.w3.org/2001/XMLSchema#string

Youn-Kyoung Lee

http://www.w3.org/2001/XMLSchema#string

P2860

Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2

Components of a new human protein kinase signal transduction pathway

The protein kinase complement of the human genome

Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling

MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway

MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway

Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control

P304

7826-31

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scholarly article

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2458236

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10.1074/JBC.M313465200

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P433

9

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P478

279

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2004-02-27T00:00:00Z

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P698

14681216

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