The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis. - Wikidata - wikimedia - TriplyDB

The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.

The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.

http://www.wikidata.org/entity/Q33782414

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Ceramide synthases at the centre of sphingolipid metabolism and biology Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate Evolving concepts in cancer therapy through targeting sphingolipid metabolism Bioactive lipids and the control of Bax pro-apoptotic activity Regulation of mitochondrial ceramide distribution by members of the BCL-2 family Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction.Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor c-Abl is an upstream regulator of acid sphingomyelinase in apoptosis induced by inhibition of integrins αvβ3 and αvβ5.Glucose availability and glycolytic metabolism dictate glycosphingolipid levels Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events.Mitochondrial Ion Channels in Cancer Transformation Ceramide channels: destabilization by Bcl-xL and role in apoptosis Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins Identification and characterization of protein phosphatase 2C activation by ceramide.Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6 BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins.Accumulation of ordered ceramide-cholesterol domains in farber disease fibroblasts.Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism.Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.p53 and Ceramide as Collaborators in the Stress Response Sphingolipids and mitochondrial apoptosis.Regulation of ceramide channel formation and disassembly: Insights on the initiation of apoptosis.Ceramide channels and mitochondrial outer membrane permeability.Cannabinoid derivatives exert a potent anti-myeloma activity both in vitro and in vivo.Alteration in Phospholipidome Profile of Myoblast H9c2 Cell Line in a Model of Myocardium Starvation and Ischemia.Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.Delivery systems of ceramide in targeted cancer therapy: ceramide alone or in combination with other anti-tumor agents.Physiological and Pharmacological Control of BAK, BAX, and Beyond.Metabolic Regulation of Apoptosis in Cancer.The indirect activation model of mitochondrial outer membrane permeabilisation (MOMP) initiation requires a trade-off between robustness in the absence of and sensitivity in the presence of stress.Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.Inter-organellar communication with mitochondria regulates both the intrinsic and extrinsic pathways of apoptosis.PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway.ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: roles of cadmium and ceramide transport.Bax, Bak and beyond - mitochondrial performance in apoptosis.Sphingolipids and their metabolism in physiology and disease.

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The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.

http://www.wikidata.org/entity/Q33782414

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.

@ast

The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.

@en

type

label

The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.

@ast

The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.

@en

prefLabel

The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.

@ast

The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.

@en

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JBC.M109.078121

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Journal of Biological Chemistry

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The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis

@en

P2093

Aimee L Edinger

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Christopher J Clarke

http://www.w3.org/2001/XMLSchema#string

Kimberly Romero Rosales

http://www.w3.org/2001/XMLSchema#string

Leah J Siskind

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María José Hernandez-Corbacho

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Thomas D Mullen

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P2860

Proapoptotic BAX and BAK control multiple initiator caspases

Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest

Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells

Trans-Golgi network and endosome dynamics connect ceramide homeostasis with regulation of the unfolded protein response and TOR signaling in yeast.

BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome

Principles of bioactive lipid signalling: lessons from sphingolipids

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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285

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20172858

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2852918

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