ADAMTS13 substrate recognition of von Willebrand factor A2 domain - Wikidata - wikimedia - TriplyDB

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

http://www.wikidata.org/entity/Q24338203

about

Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor Calcium modulates force sensing by the von Willebrand factor A2 domain Allosteric activation of ADAMTS13 by von Willebrand factor.Shear-Induced Unfolding and Enzymatic Cleavage of Full-Length VWF Multimers.Further characterization of ADAMTS-13 inactivation by thrombin.Prevalence of the ADAMTS-13 missense mutation R1060W in late onset adult thrombotic thrombocytopenic purpura.An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF Escherichia coli-derived von Willebrand factor-A2 domain fluorescence/Förster resonance energy transfer proteins that quantify ADAMTS13 activity.A shear-based assay for assessing plasma ADAMTS13 activity and inhibitors in patients with thrombotic thrombocytopenic purpura Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain Conformational activation of ADAMTS13.A model for the conformational activation of the structurally quiescent metalloprotease ADAMTS13 by von Willebrand factor.Unfolding the A2 domain of von Willebrand factor with the optical trap A model for single-substrate trimolecular enzymatic kinetics.von Willebrand factor, Jedi knight of the bloodstream The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor.Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13).Characterization of a core binding site for ADAMTS-13 in the A2 domain of von Willebrand factor.Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis.Massively parallel enzyme kinetics reveals the substrate recognition landscape of the metalloprotease ADAMTS13.A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases.Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity.Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.Translational medicine advances in von Willebrand disease.Biology and physics of von Willebrand factor concatamers.Potential value of targeting von Willebrand factor in atherosclerotic cardiovascular disease.ADAMTS-13 glycans and conformation-dependent activity.N-linked glycan truncation causes enhanced clearance of plasma-derived von Willebrand factor.The ADAMTS13 metalloprotease domain: roles of subsites in enzyme activity and specificity.The cysteine-rich domain of snake venom metalloproteinases is a ligand for von Willebrand factor A domains: role in substrate targeting.Conformational quiescence of ADAMTS-13 prevents proteolytic promiscuity.Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor.Mechanistic studies on ADAMTS13 catalysis Shear tango: dance of the ADAMTS13/VWF complex.Pathological von Willebrand factor fibers resist tissue plasminogen activator and ADAMTS13 while promoting the contact pathway and shear-induced platelet activation.Use of a mouse model to elucidate the phenotypic effects of the von Willebrand factor cleavage mutants, Y1605A/M1606A and R1597W.

P2860

2c72726b3f3cdeb24da1365b847d410179101907 5795c89fefda8cc8b1dfb419a07a0026de654ffd

P248

Q27655615-6D6BB899-27EE-4384-919A-31BB70A42BC8 Q27670774-13DB988D-F770-4EB5-ACC2-472414F181E8 Q29568910-A406D1EB-DA4E-4E2B-A9ED-C70AE860B72C Q30364288-040FC018-D3FD-40E0-B22A-5C5960410C26 Q33278139-3D32441E-64DA-4B42-932B-91728F5AEA12 Q33377517-F8E7C611-0B8F-4840-AF7D-58D84822C3E5 Q33387616-484C2161-489A-4491-8FD5-1C13FDFD04FB Q33393227-DE596122-CD39-4E16-B5F1-C15853F62C67 Q33393728-5CCFA17E-BCDB-46A2-8628-A2A7CB6A330C Q33395978-A53138B7-20AD-4675-9081-749E80455D32 Q33419359-306EB001-5DAA-4C9A-8308-3BEA80DDD81B Q33567628-510A45EE-3322-44DD-8DF6-9C161F645843 Q33795688-40104B1D-E0EC-4763-AEA7-0F0E6F258D25 Q33820902-C61005EB-D656-4EF7-A19E-0AEAA77A9ED0 Q34106824-D782B004-6482-4D2B-84FC-16E465026AAF Q34107517-A4B53890-D892-40F7-9A54-4492A05E3853 Q34196324-640C0BC4-CEA8-48B7-A392-4FA94C60F68F Q35105077-D3DAC0CF-60E3-4520-BA56-9BFF00477CF5 Q35165568-EEFA36A8-24FB-4F1E-B93C-084E59DF6638 Q35193294-3885D13C-E450-4C3F-80EC-9732D58F8BA7 Q35197446-E5BF4096-5398-4F85-B33D-3D68722D60C7 Q35690203-583FA788-5581-403C-A9F0-72B0FC202B03 Q36109433-A74AC888-52F1-452B-9C8F-F78D6D04E09F Q36137447-2B846552-A35F-448E-B862-5AE06D794B6F Q36843699-E22B17CC-871D-4397-8251-BDFC102B440D Q37317725-EC77ED43-D215-463F-9F93-99DA51F722C2 Q37428907-FAB75D38-8CE9-43CD-A19A-643E35CD5CD2 Q37602563-3E1E2C6E-1ABB-41BC-B15E-C3C0002DED1C Q37903936-B3487F24-80D9-43F4-85B0-38B6F23D2AC8 Q38145381-E2613D42-F8CE-4093-AC12-EC2C54284682 Q38859075-AD777029-4922-4E1F-A22C-231FD8CCD33A Q39299024-EC0CC793-3047-4EC0-B9F2-18666D44CB82 Q39677665-9F3119CD-9545-4A0F-AD51-0F5955D978FC Q40220379-1B41C288-2484-45DD-B46E-81FBDD58EDD9 Q41946735-2F7FB4F4-4011-4107-BA30-88CF6DE3BD3F Q42013734-943B0B60-6696-49FC-BE90-E0A855918552 Q42397144-077796BE-9BB1-4841-8E12-9FCE84D837A4 Q42404760-5A879E48-44B8-49D0-AE6E-FDAECDB0DD4A Q42581851-F87B1852-280D-4FB9-9489-E0B4D1288E18 Q55332935-84B6E917-B80C-4613-9102-5EF3B7E24376

P2860

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

http://www.wikidata.org/entity/Q24338203

description

2006 nî lūn-bûn

@nan

2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

@ast

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

@en

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

@en-gb

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

@nl

type

label

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

@ast

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

@en

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

@en-gb

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

@nl

prefLabel

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

@ast

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

@en

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

@en-gb

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

@nl

P1433

Q24338203-5368C9F4-2F7F-44E2-86B2-17449D983252

P1476

Q24338203-8160813F-1B8B-4FEE-B06E-DB85EC0E562E

P2093

Q24338203-21D44ED7-7146-4C2D-BB8C-481E3BC44609

Q24338203-596D1378-E29C-42C7-8992-4EF796763DE2

Q24338203-8298F365-487F-47A8-A427-32197FF0A31B

Q24338203-8AE09D51-3C0C-4CA3-B222-BD268C1F0B1C

P2860

Q24338203-00064552-991C-4FF6-9645-5FDBECBFAE0C

Q24338203-0AA9A18A-86F4-4229-8F37-F4722C5B72AC

Q24338203-12FCE6C4-7921-4307-B2C9-E57E705027F6

Q24338203-4826C902-0360-41B6-B658-7CC08B71B2AB

Q24338203-498F1514-73E7-493E-9C80-3147F8099768

Q24338203-54F3CF37-BBFD-4D0B-99FA-C7EE8DCF5B4B

Q24338203-69BEDB9E-6D70-4C45-9C92-7CD40C62435F

Q24338203-87AC0E90-75B0-4AD7-B94E-B11FA4C2E950

Q24338203-928CA864-E47C-4AAF-9384-94ECEA55749C

Q24338203-A733CF96-89E8-47DB-A547-4A81E719366D

P304

Q24338203-F6D3498B-A3F1-4D04-8B18-91A735C6DA16

P31

Q24338203-CB1A9CDF-9C76-4AE6-B201-462CEB0E141C

P3181

Q24338203-11427A1D-6203-4F4B-9B61-413638AC137F

P356

Q24338203-139E801F-1509-41BC-AB8A-01074DF04AE0

P407

Q24338203-22A7EAFF-B29E-4109-A384-B20A2EA11030

P433

Q24338203-A1904FEB-2B09-451D-B0AE-AA5471C6C09C

P478

Q24338203-10EFF323-721B-4EB7-B664-3FA8A72B6F3C

P50

Q24338203-3DDD9189-748B-4E60-8288-807F9AA8D37A

Q24338203-E73985C6-1F20-4413-BCBB-E3EBCE018935

P577

Q24338203-05907D48-AD32-4FD0-B326-8439034E3546

P5875

Q24338203-D5D2C82D-E028-4D70-ACCE-5A0EC87367A7

P698

Q24338203-8A4D674B-6692-49CF-9BC0-2E6881DFC0DE

P3181

P356

P1433

Journal of Biological Chemistry

P1476

ADAMTS13 substrate recognition of von Willebrand factor A2 domain

@en

P2093

Chan K N Chan Kwo Chion

http://www.w3.org/2001/XMLSchema#string

David A Lane

http://www.w3.org/2001/XMLSchema#string

Jonathan K Lam

http://www.w3.org/2001/XMLSchema#string

Sara Zanardelli

http://www.w3.org/2001/XMLSchema#string

P2860

Biochemistry and genetics of von Willebrand factor

Binding of ADAMTS13 to von Willebrand factor

ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor

ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions.

VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13.

FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay.

Platelets have more than one binding site for von Willebrand factor.

Biosynthesis, processing and secretion of von Willebrand factor: biological implications.

The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor.

Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.

P304

1555-1563

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

4000650

http://www.w3.org/2001/XMLSchema#string

P356

10.1074/JBC.M508316200

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

281

http://www.w3.org/2001/XMLSchema#string

P50

James T B Crawley

P577

2005-10-12T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7543930

http://www.w3.org/2001/XMLSchema#string

P698

16221672

http://www.w3.org/2001/XMLSchema#string