Characterization of a core binding site for ADAMTS-13 in the A2 domain of von Willebrand factor.
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Pathophysiology of thrombotic thrombocytopenic purpuraPathogenesis of thrombotic microangiopathiesStructural basis of type 2A von Willebrand disease investigated by molecular dynamics simulations and experimentsFurther characterization of ADAMTS-13 inactivation by thrombin.An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWFEscherichia coli-derived von Willebrand factor-A2 domain fluorescence/Förster resonance energy transfer proteins that quantify ADAMTS13 activity.Crystal structure and enzymatic activity of an ADAMTS-13 mutant with the East Asian-specific P475S polymorphism.ADAMTS13 and von Willebrand factor interactions.Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13.Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13.The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain functionUnraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor.Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13).Hypochlorous acid generated by neutrophils inactivates ADAMTS13: an oxidative mechanism for regulating ADAMTS13 proteolytic activity during inflammation.The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis.The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow.A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases.Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity.A systematic overview of the first pasteurised VWF/FVIII medicinal product, Haemate P/ Humate -P: history and clinical performance.Multi-step binding of ADAMTS-13 to von Willebrand factor.Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.Handling Metalloproteinases.Thrombosis and von Willebrand Factor.A novel monoclonal antibody against the von Willebrand Factor A2 domain reduces its cleavage by ADAMTS13.Mechanistic studies on ADAMTS13 catalysisShear tango: dance of the ADAMTS13/VWF complex.ADAMTS-13 and von Willebrand factor: a dynamic duo.Prediction of spacer-α6 complex: a novel insight into binding of ADAMTS13 with A2 domain of von Willebrand factor under forces.
P2860
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P2860
Characterization of a core binding site for ADAMTS-13 in the A2 domain of von Willebrand factor.
description
2006 nî lūn-bûn
@nan
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Characterization of a core bin ...... main of von Willebrand factor.
@ast
Characterization of a core bin ...... main of von Willebrand factor.
@en
type
label
Characterization of a core bin ...... main of von Willebrand factor.
@ast
Characterization of a core bin ...... main of von Willebrand factor.
@en
prefLabel
Characterization of a core bin ...... main of von Willebrand factor.
@ast
Characterization of a core bin ...... main of von Willebrand factor.
@en
P2093
P2860
P356
P1476
Characterization of a core bin ...... omain of von Willebrand factor
@en
P2093
Brad A McMullen
Jing-Jiang Wu
Kazuo Fujikawa
P2860
P304
18470-18474
P356
10.1073/PNAS.0609190103
P407
P50
P577
2006-11-22T00:00:00Z