Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion - Wikidata - wikimedia - TriplyDB

Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion

Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion

http://www.wikidata.org/entity/Q24648472

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PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis Redox homeostasis in pancreatic β cells Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy Mitochondrial regulation of β-cell function: maintaining the momentum for insulin release PCK2 activation mediates an adaptive response to glucose depletion in lung cancer Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability The mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) and glucose homeostasis: has it been overlooked?Mitochondria and cancer Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion Regulation of insulin secretion: role of mitochondrial signalling.Comparative Analysis of the Mitochondrial Physiology of Pancreatic β Cells Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release.Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells Direct Stimulation of Islet Insulin Secretion by Glycolytic and Mitochondrial Metabolites in KCl-Depolarized Islets.Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism.Aryl hydrocarbon receptor activation by dioxin targets phosphoenolpyruvate carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP).Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways.Suppression of fat deposition in broiler chickens by (-)-hydroxycitric acid supplementation: A proteomics perspective.What is the metabolic role of phosphoenolpyruvate carboxykinase?FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice.A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis.The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells.Ixodes scapularis Tick Cells Control Anaplasma phagocytophilum Infection by Increasing the Synthesis of Phosphoenolpyruvate from Tyrosine.A plant/fungal-type phosphoenolpyruvate carboxykinase located in the parasite mitochondrion ensures glucose-independent survival of Toxoplasma gondii.Fuel-Stimulated Insulin Secretion Depends upon Mitochondria Activation and the Integration of Mitochondrial and Cytosolic Substrate Cycles Metabolomic analysis of pancreatic β-cell insulin release in response to glucose.Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb's cycle flux independent of ATP synthesis.Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents.Hyperglucagonemia precedes a decline in insulin secretion and causes hyperglycemia in chronically glucose-infused rats.Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism.Kinetic and functional properties of human mitochondrial phosphoenolpyruvate carboxykinase.Neuronal Progenitor Maintenance Requires Lactate Metabolism and PEPCK-M-Directed Cataplerosis.Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle.Thematic minireview series: a perspective on the biology of phosphoenolpyruvate carboxykinase 55 years after its discovery.How do reducing equivalents increase insulin secretion?Reply to Leithner et al.: Focus on phopshoenolpyruvate carboxykinase (PEPCK): a target of the p53-SIRT6-FoxO1 axis.Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors.Glucose and lipid metabolism in the pancreas of rainbow trout is regulated at the molecular level by nutritional status and carbohydrate intake.Inhibition of connexin 36 hemichannels by glucose contributes to the stimulation of insulin secretion.

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Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion

http://www.wikidata.org/entity/Q24648472

description

2009 nî lūn-bûn

@nan

2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

@wuu

name

Phosphoenolpyruvate cycling vi ...... ial GTP with insulin secretion

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Phosphoenolpyruvate cycling vi ...... ial GTP with insulin secretion

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Phosphoenolpyruvate cycling vi ...... ial GTP with insulin secretion

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type

label

Phosphoenolpyruvate cycling vi ...... ial GTP with insulin secretion

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Phosphoenolpyruvate cycling vi ...... ial GTP with insulin secretion

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Phosphoenolpyruvate cycling vi ...... ial GTP with insulin secretion

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Phosphoenolpyruvate cycling vi ...... ial GTP with insulin secretion

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Phosphoenolpyruvate cycling vi ...... ial GTP with insulin secretion

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Phosphoenolpyruvate cycling vi ...... ial GTP with insulin secretion

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JBC.M109.011775

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Journal of Biological Chemistry

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Phosphoenolpyruvate cycling vi ...... ial GTP with insulin secretion

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Adina Turcu

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Francisco Pasquel

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Gary W Cline

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Michael Roden

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Rebecca L Pongratz

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Richard G Kibbey

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Romana Stark

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P2860

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets

Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion

The mitochondrial transporter family (SLC25): physiological and pathological implications

Structural insights into the mechanism of PEPCK catalysis

A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion

Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver

Mitochondrial GTP regulates glucose-stimulated insulin secretion

Human mitochondrial phosphoenolpyruvate carboxykinase 2 gene. Structure, chromosomal localization and tissue-specific expression

Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells

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10.1074/JBC.M109.011775

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39

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