Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status
about
Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formationThe novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressorEmerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical exampleResidues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitroMild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins.The complex interactions of p53 with target DNA: we learn as we go.Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts.Role of a tryptophan anchor in human topoisomerase I structure, function and inhibition.Nucleolar control of p53: a cellular Achilles' heel and a target for cancer therapy.Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells.Altered phosphorylation of topoisomerase I following overexpression in an ovarian cancer cell line.Distinct effects of topoisomerase I and RNA polymerase I inhibitors suggest a dual mechanism of nucleolar/nucleoplasmic partitioning of topoisomerase I.Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin.The N-terminal domain anchors human topoisomerase I at fibrillar centers of nucleoli and nucleolar organizer regions of mitotic chromosomes.Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.Nucleolar AATF regulates c-Jun-mediated apoptosis.Topoisomerase II, not topoisomerase I, is the proficient relaxase of nucleosomal DNA.Dynamics of tobacco DNA topoisomerases II in cell cycle regulation: to manage topological constrains during replication, transcription and mitotic chromosome condensation and segregation.The tumor suppressor protein p53 stimulates the formation of the human topoisomerase I double cleavage complex in vitro
P2860
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P2860
Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
Subnuclear distribution of top ...... g transcription and p53 status
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Subnuclear distribution of top ...... g transcription and p53 status
@en
Subnuclear distribution of top ...... g transcription and p53 status
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Subnuclear distribution of top ...... g transcription and p53 status
@nl
type
label
Subnuclear distribution of top ...... g transcription and p53 status
@ast
Subnuclear distribution of top ...... g transcription and p53 status
@en
Subnuclear distribution of top ...... g transcription and p53 status
@en-gb
Subnuclear distribution of top ...... g transcription and p53 status
@nl
prefLabel
Subnuclear distribution of top ...... g transcription and p53 status
@ast
Subnuclear distribution of top ...... g transcription and p53 status
@en
Subnuclear distribution of top ...... g transcription and p53 status
@en-gb
Subnuclear distribution of top ...... g transcription and p53 status
@nl
P2093
P2860
P3181
P356
P1476
Subnuclear distribution of top ...... g transcription and p53 status
@en
P2093
Issac R Mehl
Mark T Muller
Yinghui Mao
P2860
P304
P3181
P356
10.1073/PNAS.022631899
P407
P577
2002-02-05T00:00:00Z