Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro
about
Rotation of DNA around intact strand in human topoisomerase I implies distinct mechanisms for positive and negative supercoil relaxationTDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and IIRole of a tryptophan anchor in human topoisomerase I structure, function and inhibition.Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.Sequence selectivity of the cleavage sites induced by topoisomerase I inhibitors: a molecular dynamics study.Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells.C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo.Role of the linker domain and the 203-214 N-terminal residues in the human topoisomerase I DNA complex dynamics.Distinct effects of topoisomerase I and RNA polymerase I inhibitors suggest a dual mechanism of nucleolar/nucleoplasmic partitioning of topoisomerase I.A novel approach for organelle-specific DNA damage targeting reveals different susceptibility of mitochondrial DNA to the anticancer drugs camptothecin and topotecan.Subnuclear Localization of Human Topoisomerase I.
P2860
Q24814522-BC200463-242B-4026-A24F-4EEAAAA7008BQ28288660-0C0DDB15-7A04-4D62-B70A-E445CD7E7EB0Q37217081-54589601-EF0D-4171-9CF1-47CDAD1B5243Q37406087-C520E75C-BD95-4817-ABDE-A5B7E5543BE9Q37528750-B4694164-B4B2-47D3-93CF-113E46378EACQ39551829-843CC520-E07E-48BE-9D82-C8CB51EE57CDQ40127799-482A8F8D-AF4A-4397-865C-D4F04DF25E64Q40308617-038B720C-C0DB-473B-9E6E-FE0D35E63686Q40579913-29218166-EEED-47BB-8048-9E1D0757F2EFQ43167728-7E465DA0-9EDE-43DD-A8CD-94D5AD4E9F85Q51634807-5356B4C8-98D2-49A9-B16A-46E091D728CE
P2860
Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro
description
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Dezember 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
wetenschappelijk artikel (gepubliceerd op 2003/12/15)
@nl
наукова стаття, опублікована в грудні 2003
@uk
مقالة علمية (نشرت في 15-12-2003)
@ar
name
Residues 190-210 of human topo ...... ivity in vivo but not in vitro
@ast
Residues 190-210 of human topo ...... ivity in vivo but not in vitro
@en
type
label
Residues 190-210 of human topo ...... ivity in vivo but not in vitro
@ast
Residues 190-210 of human topo ...... ivity in vivo but not in vitro
@en
prefLabel
Residues 190-210 of human topo ...... ivity in vivo but not in vitro
@ast
Residues 190-210 of human topo ...... ivity in vivo but not in vitro
@en
P2093
P2860
P3181
P356
P1476
Residues 190-210 of human topo ...... ivity in vivo but not in vitro
@en
P2093
Christian Mielke
Hans U. Barthelmes
Morten O. Christensen
P2860
P304
P3181
P356
10.1093/NAR/GKG927
P407
P50
P577
2003-12-15T00:00:00Z