A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor
about
Systematic identification of regulatory proteins critical for T-cell activationFunctional interaction of caveolin-1 with Bruton's tyrosine kinase and BmxThe proline rich region of the Tec homology domain of ITK regulates its activityRap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1The Tec family kinase Itk exists as a folded monomer in vivo.Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors.Localization of Tec29 to ring canals is mediated by Src64 and PtdIns(3,4,5)P3-dependent mechanisms.CD28 and ITK signals regulate autoreactive T cell trafficking.Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs.The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factorDifferential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells.T-cell receptor signaling to integrins.Genetic analysis of integrin activation in T lymphocytes.The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.Itk: the rheostat of the T cell response.Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial.The TCR ADAPts to integrin-mediated cell adhesion.Peroxisome degradation requires catalytically active sterol glucosyltransferase with a GRAM domain.Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in MiceResistance to TGF-beta 1 correlates with aberrant expression of TGF-beta receptor II in human B-cell lymphoma cell lines.Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90+ study.TEC-family kinases: regulators of T-helper-cell differentiation.Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.Intracellular signalling controlling integrin activation in lymphocytes.Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrinsCXCL12-induced partitioning of flotillin-1 with lipid rafts plays a role in CXCR4 functionTec kinases, actin, and cell adhesion.Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/TxkITK inhibitors in inflammation and immune-mediated disorders.The role of Tec family kinases in the regulation of T-helper-cell differentiation.Regulation of T-cell responses and disease by tec kinase Itk.Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse.The lymphoma-associated fusion tyrosine kinase ITK-SYK requires pleckstrin homology domain-mediated membrane localization for activation and cellular transformation.WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse.The beta1 and beta3 integrins promote T cell receptor-mediated cytotoxic T lymphocyte activation.Chemokine stimulation of lymphocyte alpha 4 integrin avidity but not of leukocyte function-associated antigen-1 avidity to endothelial ligands under shear flow requires cholesterol membrane rafts.Selective activation of small GTPase RhoA by tyrosine kinase Etk through its pleckstrin homology domain.Tec kinases regulate actin assembly and cytokine expression in LPS-stimulated human neutrophils via JNK activation.LFA-1 regulates CD8+ T cell activation via T cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathways.AoAtg26, a putative sterol glucosyltransferase, is required for autophagic degradation of peroxisomes, mitochondria, and nuclei in the filamentous fungus Aspergillus oryzae.
P2860
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P2860
A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
A novel function for the Tec f ...... tegrins by the T-cell receptor
@ast
A novel function for the Tec f ...... tegrins by the T-cell receptor
@en
A novel function for the Tec f ...... tegrins by the T-cell receptor
@nl
type
label
A novel function for the Tec f ...... tegrins by the T-cell receptor
@ast
A novel function for the Tec f ...... tegrins by the T-cell receptor
@en
A novel function for the Tec f ...... tegrins by the T-cell receptor
@nl
prefLabel
A novel function for the Tec f ...... tegrins by the T-cell receptor
@ast
A novel function for the Tec f ...... tegrins by the T-cell receptor
@en
A novel function for the Tec f ...... tegrins by the T-cell receptor
@nl
P2093
P2860
P356
P1433
P1476
A novel function for the Tec f ...... tegrins by the T-cell receptor
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/20.6.1232
P407
P577
2001-03-15T00:00:00Z