Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP. - Wikidata - wikimedia - TriplyDB

Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.

Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.

http://www.wikidata.org/entity/Q36158629

about

Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1.Wiskott-Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cells Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells Discs Large Homolog 1 Splice Variants Regulate p38-Dependent and -Independent Effector Functions in CD8+ T Cells.Regulation of immune responsiveness in vivo by disrupting an early T-cell signaling event using a cell-permeable peptide.In vivo significance of ITK-SLP-76 interaction in cytokine production.SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics The unique localization of ZFP185 at uropod of mouse T lymphocytes.The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factor Btk regulates B cell receptor-mediated antigen processing and presentation by controlling actin cytoskeleton dynamics in B cells.Innate PLZF+CD4+ αβ T cells develop and expand in the absence of Itk.Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells.T-cell signaling regulated by the Tec family kinase, Itk.The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein.T-cell receptor signaling to integrins.ERK positive feedback regulates a widespread network of tyrosine phosphorylation sites across canonical T cell signaling and actin cytoskeletal proteins in Jurkat T cells.Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking.Itk: the rheostat of the T cell response.Impairment of immunological synapse formation in adaptively tolerant T cells Regulation of cytoskeletal dynamics at the immune synapse: new stars join the actin troupe Itk controls the spatiotemporal organization of T cell activation.T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia.TEC-family kinases: regulators of T-helper-cell differentiation.Intracellular signalling controlling integrin activation in lymphocytes.eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1.Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization.Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug.Tec kinases, actin, and cell adhesion.Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis.Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes n-3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activation.Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activation ITK inhibitors in inflammation and immune-mediated disorders.

P2860

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P2860

Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.

http://www.wikidata.org/entity/Q36158629

description

2003 nî lūn-bûn

@nan

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

2003年论文

@zh

2003年论文

@zh-cn

name

Itk functions to control actin ...... activation of Cdc42 and WASP.

@ast

Itk functions to control actin ...... activation of Cdc42 and WASP.

@en

type

label

Itk functions to control actin ...... activation of Cdc42 and WASP.

@ast

Itk functions to control actin ...... activation of Cdc42 and WASP.

@en

prefLabel

Itk functions to control actin ...... activation of Cdc42 and WASP.

@ast

Itk functions to control actin ...... activation of Cdc42 and WASP.

@en

P1433

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P932

Q36158629-9823DE2D-D751-44FD-B5BA-2EC42BE2DA51

P356

J.CUB.2003.08.005

P1433

Current Biology

P1476

Itk functions to control actin ...... activation of Cdc42 and WASP.

@en

P2093

Abhinav Seth

http://www.w3.org/2001/XMLSchema#string

Ana Takesono

http://www.w3.org/2001/XMLSchema#string

Carol M Lewis

http://www.w3.org/2001/XMLSchema#string

Christine M Labno

http://www.w3.org/2001/XMLSchema#string

Daisy W Leung

http://www.w3.org/2001/XMLSchema#string

Daoqi You

http://www.w3.org/2001/XMLSchema#string

Janis K Burkhardt

http://www.w3.org/2001/XMLSchema#string

Lisa D Finkelstein

http://www.w3.org/2001/XMLSchema#string

Michael K Rosen

http://www.w3.org/2001/XMLSchema#string

Natalie Kamberos

http://www.w3.org/2001/XMLSchema#string

P2860

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav

Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein

A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor

Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization

Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex

Xid-like phenotypes: a B cell signalosome takes shape

The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization

Identification of Itk/Tsk Src homology 3 domain ligands

The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

P304

1619-1624

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scholarly article

P356

10.1016/J.CUB.2003.08.005

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P407

P433

18

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P478

13

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P577

2003-09-01T00:00:00Z

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P5875

9887284

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13678593

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P932

3417328

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