WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse. - Wikidata - wikimedia - TriplyDB

WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse.

WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse.

http://www.wikidata.org/entity/Q40115442

about

A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding.Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse T Lymphocyte Migration: An Action Movie Starring the Actin and Associated Actors.WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site A novel flow cytometric high throughput assay for a systematic study on molecular mechanisms underlying T cell receptor-mediated integrin activation WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization.F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse.Prolactin-induced protein is required for cell cycle progression in breast cancer.The final steps of integrin activation: the end game IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.Bacterial subversion of host actin dynamics at the plasma membrane.SNX17 affects T cell activation by regulating TCR and integrin recycling New insights into vinculin function and regulation.GRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A Contact-dependent T cell activation and T cell stopping require talin1 Substrate rigidity regulates human T cell activation and proliferation Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells.The emerging role of protein kinase Cθ in cytoskeletal signaling.The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1.Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation Adhesions ring: a structural comparison between podosomes and the immune synapse.Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse.Abl tyrosine kinases in T-cell signaling n-3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activation.Signal transduction during activation and inhibition of natural killer cells.Hepatitis B Virus Protein X Induces Degradation of Talin-1.Vinculin nucleates actin polymerization and modifies actin filament structure.Modular design of immunological synapses and kinapses.A conformational change within the WAVE2 complex regulates its degradation following cellular activation Multiple pathways leading from the T-cell antigen receptor to the actin cytoskeleton network.New insights into the T cell synapse from single molecule techniques.T cell antigen receptor activation and actin cytoskeleton remodeling.Plasma membrane--cortical cytoskeleton interactions: a cell biology approach with biophysical considerations.Wiskott-Aldrich syndrome protein--dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes.Cofilin: a redox sensitive mediator of actin dynamics during T-cell activation and migration.Adaptor regulation of LFA-1 signaling in T lymphocyte migration: Potential druggable targets for immunotherapies?Molecular control of B cell activation and immunological synapse formation.Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool.

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P2860

WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse.

http://www.wikidata.org/entity/Q40115442

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

WAVE2 regulates high-affinity ...... to the immunological synapse.

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type

label

WAVE2 regulates high-affinity ...... to the immunological synapse.

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prefLabel

WAVE2 regulates high-affinity ...... to the immunological synapse.

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Molecular and Cellular Biology

P1476

WAVE2 regulates high-affinity ...... n to the immunological synapse

@en

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Bruce D Freedman

http://www.w3.org/2001/XMLSchema#string

Daniel D Billadeau

http://www.w3.org/2001/XMLSchema#string

Jason S Mitchell

http://www.w3.org/2001/XMLSchema#string

Jeffrey C Nolz

http://www.w3.org/2001/XMLSchema#string

Peimin Zhu

http://www.w3.org/2001/XMLSchema#string

Ricardo B Medeiros

http://www.w3.org/2001/XMLSchema#string

P2860

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion

RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion

Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein

A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor

The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis

Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1

VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses

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5986-6000

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scholarly article

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10.1128/MCB.00136-07

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17

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27

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2007-06-25T00:00:00Z

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17591693

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1952166

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