Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. - Wikidata - wikimedia - TriplyDB

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

http://www.wikidata.org/entity/Q24538300

about

Chk1 suppressed cell death MDC1 is a mediator of the mammalian DNA damage checkpoint Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway Dual phosphorylation controls Cdc25 phosphatases and mitotic entry DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases.Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2 Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest Targeting DNA Replication Stress for Cancer Therapy The DNA damage response induced by infection with human cytomegalovirus and other viruses LB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potential Genomic instability in cancer.Human claspin is required for replication checkpoint control SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase Phosphorylation of the regulatory beta-subunit of protein kinase CK2 by checkpoint kinase Chk1: identification of the in vitro CK2beta phosphorylation site Roles of Chk1 in cell biology and cancer therapy The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons Regulating mammalian checkpoints through Cdc25 inactivation.Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation The role of Cdc25A in the regulation of cell proliferation and apoptosis Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer.CDC25A phosphatase controls meiosis I progression in mouse oocytes.Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase.Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage ATR and ATM regulate the timing of DNA replication origin firing.Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding The Arabidopsis thaliana checkpoint kinase WEE1 protects against premature vascular differentiation during replication stress.Phase I dose-escalation study to examine the safety and tolerability of LY2603618, a checkpoint 1 kinase inhibitor, administered 1 day after pemetrexed 500 mg/m(2) every 21 days in patients with cancer MEPE/OF45 as a new target for sensitizing human tumour cells to DNA damage inducers Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy

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P2860

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

http://www.wikidata.org/entity/Q24538300

description

2002 nî lūn-bûn

@nan

2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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name

Disruption of the checkpoint k ...... n-induced S and G2 checkpoints

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Disruption of the checkpoint k ...... -induced S and G2 checkpoints.

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Disruption of the checkpoint k ...... -induced S and G2 checkpoints.

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type

label

Disruption of the checkpoint k ...... n-induced S and G2 checkpoints

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Disruption of the checkpoint k ...... -induced S and G2 checkpoints.

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Disruption of the checkpoint k ...... -induced S and G2 checkpoints.

@en

prefLabel

Disruption of the checkpoint k ...... n-induced S and G2 checkpoints

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Disruption of the checkpoint k ...... -induced S and G2 checkpoints.

@ast

Disruption of the checkpoint k ...... -induced S and G2 checkpoints.

@en

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Proceedings of the National Academy of Sciences of the United States of America

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Disruption of the checkpoint k ...... -induced S and G2 checkpoints.

@en

P2093

Helen Piwnica-Worms

http://www.w3.org/2001/XMLSchema#string

Hui Zhao

http://www.w3.org/2001/XMLSchema#string

Janis L Watkins

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P2860

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

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14795-14800

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1074243

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10.1073/PNAS.182557299

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23

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99

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8676253

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12399544

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137498

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