CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents
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Capturing Biological Activity in Natural Product Fragments by Chemical SynthesisStrategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer TherapeuticsAntibody-drug conjugates as novel anti-cancer chemotherapeuticsStructural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin AnaloguesSolution structure of a highly stable DNA duplex conjugated to a minor groove binderChemical proteomics approaches for identifying the cellular targets of natural productsA fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding.Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs.An additional spirocyclization for duocarmycin SASynthesis and characterization of a cyclobutane duocarmycin derivative incorporating the 1,2,10,11-tetrahydro-9H-cyclobuta[c]benzo[e]indol-4-one (CbBI) alkylation subunit.Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunitDesign, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activationAsymmetric synthesis of a CBI-based cyclic N-acyl O-amino phenol duocarmycin prodrug.Rapid and efficient hybridization-triggered crosslinking within a DNA duplex by an oligodeoxyribonucleotide bearing a conjugated cyclopropapyrroloindole.Oligonucleotides with conjugated dihydropyrroloindole tripeptides: base composition and backbone effects on hybridization.Asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI).A five-membered lactone prodrug of CBI-based analogs of the duocarmycinsA novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct.Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer.A unique class of duocarmycin and CC-1065 analogues subject to reductive activation.Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity.Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs.Distamycin A modulates the sequence specificity of DNA alkylation by duocarmycin ATotal synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycinChemistry of minor groove binder-oligonucleotide conjugates.Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065.Synthesis and evaluation of a thio analogue of duocarmycin SA.A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer ModelsSite-specific antibody drug conjugates for cancer therapySequence-specific arrest of primer extension on single-stranded DNA by an oligonucleotide-minor groove binder conjugateRecent advances in the total synthesis of cyclopropane-containing natural products.Metal-mediated targeting in the body.Cytochrome P450-activated prodrugs.Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit.Synthesis-enabled probing of mitosene structural space leads to improved IC₅₀ over mitomycin C.Evaluation of a reductively activated duocarmycin prodrug against murine and human solid cancers.Minor Groove 3-Deaza-Adenosine Analogues: Synthesis and Bypass in Translesion DNA Synthesis.Duocarmycin analogues target aldehyde dehydrogenase 1 in lung cancer cells.A repair competition assay to assess recognition by human nucleotide excision repair.
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CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents
description
1995 nî lūn-bûn
@nan
1995 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
CC-1065 and the duocarmycins: ...... derived DNA alkylating agents
@ast
CC-1065 and the duocarmycins: ...... derived DNA alkylating agents
@en
CC-1065 and the duocarmycins: ...... derived DNA alkylating agents
@nl
type
label
CC-1065 and the duocarmycins: ...... derived DNA alkylating agents
@ast
CC-1065 and the duocarmycins: ...... derived DNA alkylating agents
@en
CC-1065 and the duocarmycins: ...... derived DNA alkylating agents
@nl
prefLabel
CC-1065 and the duocarmycins: ...... derived DNA alkylating agents
@ast
CC-1065 and the duocarmycins: ...... derived DNA alkylating agents
@en
CC-1065 and the duocarmycins: ...... derived DNA alkylating agents
@nl
P2860
P3181
P356
P1476
CC-1065 and the duocarmycins: ...... derived DNA alkylating agents
@en
P2093
D S Johnson
P2860
P304
P3181
P356
10.1073/PNAS.92.9.3642
P407
P577
1995-04-25T00:00:00Z