Structural and mechanistic insights into the interaction of cytochrome P4503A4 with bromoergocryptine, a type I ligand
about
Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problemsThe structural biology of oestrogen metabolismStructural diversity of eukaryotic membrane cytochrome p450sConformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine MoleculesInteraction of human cytochrome P4503A4 with ritonavir analogsA multiscale approach to modelling drug metabolism by membrane-bound cytochrome P450 enzymesKinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11Recent Structural Insights into Cytochrome P450 Function.Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexesA large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET).Fungal cytochrome P450 monooxygenases of Fusarium oxysporum for the synthesis of ω-hydroxy fatty acids in engineered Saccharomyces cerevisiae.Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand InteractionsIn Silico Predictions of Drug - Drug Interactions Caused by CYP1A2, 2C9 and 3A4 Inhibition - a Comparative Study of Virtual Screening Performance.Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.Stereoselective formation and metabolism of 4-hydroxy-retinoic Acid enantiomers by cytochrome p450 enzymes.Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR SpectroscopyCharacterizing the membrane-bound state of cytochrome P450 3A4: structure, depth of insertion, and orientation.The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4.Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity.Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme 'active site' pocket plays a relatively 'passive role' in some enzyme-substrate interactionsThe Cytochrome P450 3A4 Has Three Major Conformations: New Clues to Drug Recognition by this Promiscuous Enzyme.Dissecting the Cytochrome P450 1A2- and 3A4-Mediated Metabolism of Aflatoxin B1 in Ligand and Protein Contributions.Nanodiscs in Membrane Biochemistry and Biophysics.Spectroscopic studies of the cytochrome P450 reaction mechanisms.Flavin-Dependent Redox Transfers by the Two-Component Diketocamphane Monooxygenases of Camphor-Grown Pseudomonas putida NCIMB 10007.Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame.Halogen-π Interactions in the Cytochrome P450 Active Site: Structural Insights into Human CYP2B6 Substrate Selectivity.Use of phenoxyaniline analogs to generate biochemical insights into polybrominated diphenyl ether interaction with CYP2B enzymes.The X-Ray Crystal Structure of the Human Mono-Oxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5.High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4.Allosteric activation of cytochrome P450 3A4 by efavirenz facilitates midazolam binding.Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates trans-retinol to 3,4-dehydroretinol.Investigation of ligand selectivity in CYP3A7 by molecular dynamics simulations.Murburn Concept: A Molecular Explanation for Hormetic and Idiosyncratic Dose Responses.
P2860
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P2860
Structural and mechanistic insights into the interaction of cytochrome P4503A4 with bromoergocryptine, a type I ligand
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structural and mechanistic ins ...... oergocryptine, a type I ligand
@ast
Structural and mechanistic ins ...... oergocryptine, a type I ligand
@en
Structural and mechanistic ins ...... oergocryptine, a type I ligand
@nl
type
label
Structural and mechanistic ins ...... oergocryptine, a type I ligand
@ast
Structural and mechanistic ins ...... oergocryptine, a type I ligand
@en
Structural and mechanistic ins ...... oergocryptine, a type I ligand
@nl
altLabel
Structural and Mechanistic Ins ...... oergocryptine, a Type I Ligand
@en
prefLabel
Structural and mechanistic ins ...... oergocryptine, a type I ligand
@ast
Structural and mechanistic ins ...... oergocryptine, a type I ligand
@en
Structural and mechanistic ins ...... oergocryptine, a type I ligand
@nl
P2860
P356
P1476
Structural and mechanistic ins ...... oergocryptine, a type I ligand
@en
P2093
Irina F Sevrioukova
Thomas L Poulos
P2860
P304
P356
10.1074/JBC.M111.317081
P407
P577
2012-01-27T00:00:00Z