Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
about
Structural and mechanistic insights into the interaction of cytochrome P4503A4 with bromoergocryptine, a type I ligandUnderstanding the mechanism of cytochrome P450 3A4: recent advances and remaining problemsThe structural biology of oestrogen metabolismStructural diversity of eukaryotic membrane cytochrome p450sPyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than RitonavirInteraction of human cytochrome P4503A4 with ritonavir analogsCYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET)Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET)A Phase Ib Study of Sorafenib (BAY 43-9006) in Patients with Kaposi Sarcoma.Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen.Structural differences between soluble and membrane bound cytochrome P450sMechanism-based inactivation of human cytochrome P450 3A4 by two piperazine-containing compoundsConcurrent cooperativity and substrate inhibition in the epoxidation of carbamazepine by cytochrome P450 3A4 active site mutants inspired by molecular dynamics simulations.Effect of ultra-high pressure homogenization on the interaction between bovine casein micelles and ritonavir.Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.Organic carbamates in drug design and medicinal chemistryImproving adherence to research protocol drug exclusions using a clinical alerting systemRitonavir analogues as a probe for deciphering the cytochrome P450 3A4 inhibitory mechanismCurrent Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand InteractionsIn Silico Predictions of Drug - Drug Interactions Caused by CYP1A2, 2C9 and 3A4 Inhibition - a Comparative Study of Virtual Screening Performance.Pharmacokinetic interactions between artesunate-mefloquine and ritonavir-boosted lopinavir in healthy Thai adultsHuman hepatocyte assessment of imatinib drug-drug interactions - complexities in clinical translation.Pharmacokinetic Interactions Between Quinine and Lopinavir/Ritonavir in Healthy Thai AdultsCytochrome P450 3A5 plays a prominent role in the oxidative metabolism of the anti-human immunodeficiency virus drug maravirocStereoselective formation and metabolism of 4-hydroxy-retinoic Acid enantiomers by cytochrome p450 enzymes.Accounting for receptor flexibility and enhanced sampling methods in computer-aided drug design.Characterizing the membrane-bound state of cytochrome P450 3A4: structure, depth of insertion, and orientation.N-Heterocyclic Carbene Capture by Cytochrome P450 3A4The effect of ritonavir on human CYP2B6 catalytic activity: heme modification contributes to the mechanism-based inactivation of CYP2B6 and CYP3A4 by ritonavirRitonavir and efavirenz significantly alter the metabolism of erlotinib--an observation in primary cultures of human hepatocytes that is relevant to HIV patients with cancer.Structure-Based Inhibitor Design for Evaluation of a CYP3A4 Pharmacophore Model.The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4.Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo.Substrate inhibition kinetics in drug metabolism reactions.Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling.Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug-drug interactions.Conformational diversity and ligand tunnels of mammalian cytochrome P450s.Classification Models for Predicting Cytochrome P450 Enzyme-Substrate Selectivity.Computational interaction analysis of organophosphorus pesticides with different metabolic proteins in humans.The kinetic mechanism for cytochrome P450 metabolism of type II binding compounds: evidence supporting direct reduction.
P2860
Q24598661-6DC9577D-9589-4468-AD17-626204B825CAQ26861370-42961970-8C12-4A5E-9213-9AEBA516E49CQ27009283-1EA19038-3DC1-4858-A9AD-132E0165747EQ27025716-8E31699F-486C-42CB-BFD7-C442745343B7Q27677369-C6A74DDB-DF2C-49A6-92B7-6A2BAAFCA381Q27678008-41DCD5D4-06CC-4850-BE71-18DD608E13F1Q28307304-D55E354F-0DD0-4EFE-BCCE-10E2C6F9A3FBQ30511797-41B0FB4E-63C7-4E49-8E9F-22426269B433Q33440392-D929490E-5F70-4AD6-B8EF-F6E363F84CA8Q34279676-1FCBCAF1-925D-4BC6-A56A-74B297550B8BQ34307948-B85F9D01-CE79-41B1-93A2-C3BB1553D4D1Q34575026-360225F4-EEBB-4420-A04D-2E1E1FA6834DQ35027093-BF6F4EA2-10DB-4BD0-AC50-722EC70091ADQ35085798-DDAAA10B-3432-411F-9A90-3FA445DA24B9Q35102625-733D6187-FD01-4EBB-A7EE-EFA9AC266215Q35365543-FE5A9B3F-0912-40BC-A8B2-55EDF5466D85Q35625350-CEC1BC1A-8813-44A6-866B-3EA763244118Q35933538-A6150944-1BAA-40E7-A994-F3D3E91FA11CQ35939821-3545F9A4-8010-44C6-B52B-4B34455E8117Q36094897-F417AE4B-E57D-4BDA-9A07-430BD0455C6DQ36144257-1DEF690C-95A2-41CF-8E41-3966C14B32FAQ36243653-4522AECE-A980-478E-8F2C-94C845FF01FFQ36359372-51C2E7C0-7782-4DFE-BE62-B43ED03F198CQ36406298-79F2D927-0BEE-46F3-BAB3-426B8308E863Q36452010-1EEA1BC4-5F13-4A63-94DE-A658601C1538Q36520871-642BA338-5F1E-4F9A-B745-B6692019242CQ36928692-FF855CF0-3822-47FD-9413-A2A1CF7BBE5CQ37062535-23F9D041-7DC4-4D8B-B0C0-DEF0A460AD68Q37193089-04747ED4-019F-4A90-BAB3-A4B776A054CCQ37193103-E4449AC2-5CB8-481A-8C46-7C1A6475ADABQ37207332-1676018B-A32A-45CA-AD9E-ABEF733B0E6EQ37308650-D3BD6B9A-7B7E-40D5-8CD8-C85691FF3387Q37355552-B787B947-B356-4282-BB32-29013C499B18Q37941118-7AF1D301-6871-4976-8896-7664C70F6E2DQ37975545-BF8C881D-BA13-4047-A899-D4B5FECD5B08Q38048826-4F925090-C6E1-4C49-B821-A6831BC86582Q38099062-CB00BBD5-5A32-4156-939D-C6A9B870C919Q39539359-E557E7A2-DF98-440B-BC83-3F88A2A10DA2Q41159732-ED1751D1-8745-42B0-A319-9F963BAFAB2FQ42128355-BDFEFF37-7875-481E-B450-975857B80E0B
P2860
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
@ast
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
@en
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
@nl
type
label
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
@ast
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
@en
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
@nl
prefLabel
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
@ast
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
@en
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
@nl
P2860
P356
P1476
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
@en
P2093
Irina F Sevrioukova
Thomas L Poulos
P2860
P304
P356
10.1073/PNAS.1010693107
P407
P577
2010-10-26T00:00:00Z