Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems
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Complexity of vitamin E metabolismAllosteric cross-talk in chromatin can mediate drug-drug synergy.Concurrent cooperativity and substrate inhibition in the epoxidation of carbamazepine by cytochrome P450 3A4 active site mutants inspired by molecular dynamics simulations.A large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET).Ritonavir analogues as a probe for deciphering the cytochrome P450 3A4 inhibitory mechanismCharacterization of the genetic variation present in CYP3A4 in three South African populations.Characterizing the membrane-bound state of cytochrome P450 3A4: structure, depth of insertion, and orientation.The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4Identification of key licorice constituents which interact with cytochrome P450: evaluation by LC/MS/MS cocktail assay and metabolic profiling.Redox-dependent stability, protonation, and reactivity of cysteine-bound heme proteins.Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes.Conformational Heterogeneity and the Affinity of Substrate Molecular Recognition by Cytochrome P450cam.Hsa-miR-27a is involved in the regulation of CYP3A4 expression in human livers from Chinese Han population.Spectroscopic studies of the cytochrome P450 reaction mechanisms.Screening of drug metabolizing enzymes for fusidic acid and its interactions with isoform-selective substrates in vitro.Importance of H-abstraction in the final step of nitrosoalkane formation in the mechanism-based inactivation of cytochrome P450 by amine-containing drugsHow is a metabolic intermediate formed in the mechanism-based inactivation of cytochrome P450 by using 1,1-dimethylhydrazine: hydrogen abstraction or nitrogen oxidation?C-H functionalization: thoroughly tuning ligands at a metal ion, a chemist can greatly enhance catalyst's activity and selectivity.Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human.Analysis of Mechanism-Based Inhibition of CYP 3A4 by a Series of Fluoroquinolone Antibacterial Agents.Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by anti-tumor triazoloacridinone C-1305.Piperine-mediated drug interactions and formulation strategy for piperine: recent advances and future perspectives.In vitro metabolism study of a novel P38 kinase inhibitor: in silico predictions, structure elucidation using MS/MS-I.Decreased elimination clearance of midazolam by doxorubicin through reductions in the metabolic activity of hepatic CYP3A in rats.7,8-benzoflavone binding to human cytochrome P450 3A4 reveals complex fluorescence quenching, suggesting binding at multiple protein sites.The potent mechanism-based inactivation of CYP2D6 and CYP3A4 with fusidic acid in in vivo bioaccumulation.Phenotyping of CYP450 in human liver microsomes using the cocktail approach.Pomegranate juice does not affect the disposition of simvastatin in healthy subjects.The McClure and Weiss models of Fe-O2 bonding for oxyhemes, and the HbO2 + NO reaction.Effects of polymorphic variation on the thermostability of heterogenous populations of CYP3A4 and CYP2C9 enzymes in solution
P2860
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P2860
Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems
description
2013 nî lūn-bûn
@nan
2013 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մարտին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Understanding the mechanism of ...... dvances and remaining problems
@ast
Understanding the mechanism of ...... dvances and remaining problems
@en
Understanding the mechanism of ...... dvances and remaining problems
@nl
type
label
Understanding the mechanism of ...... dvances and remaining problems
@ast
Understanding the mechanism of ...... dvances and remaining problems
@en
Understanding the mechanism of ...... dvances and remaining problems
@nl
prefLabel
Understanding the mechanism of ...... dvances and remaining problems
@ast
Understanding the mechanism of ...... dvances and remaining problems
@en
Understanding the mechanism of ...... dvances and remaining problems
@nl
P2860
P356
P1433
P1476
Understanding the mechanism of ...... dvances and remaining problems
@en
P2093
Irina F. Sevrioukova
Thomas L. Poulos
P2860
P304
P356
10.1039/C2DT31833D
P407
P577
2013-03-07T00:00:00Z