Structural and biochemical basis of apoptotic activation by Smac/DIABLO
about
SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membraneXIAP: cell death regulation meets copper homeostasisAlterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: A proteomic viewPellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-αApoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs.Upstream regulatory role for XIAP in receptor-mediated apoptosisAutocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosisCaspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosisThe anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sitesThe inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activityOpposite regulation of XIAP and Smac/DIABLO in the rat endometrium in response to 17beta-estradiol at estrusBench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury.SMAC is expressed de novo in a subset of cervical cancer tumorsA comparison of programmed cell death between species.Targeting Cell Survival Proteins for Cancer Cell DeathNovel strategies to target the ubiquitin proteasome system in multiple myelomaSmall-molecule SMAC mimetics as new cancer therapeuticsTargeting the apoptosis pathway in hematologic malignanciesMolecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitinationXIAP Induces NF-κB Activation via the BIR1/TAB1 Interaction and BIR1 DimerizationCrystal Structure of the BIR1 Domain of XIAP in Two Crystal FormsStructural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICEDiscovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosisEndogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosisApoptosis induces efflux of the mitochondrial matrix enzyme deoxyguanosine kinaseThe serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activityMolecular characterization of CD40 signaling intermediatesCaspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondriaEctopic expression of new alternative splice variant of Smac/DIABLO increases mammospheres formationApollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection functionThe membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9General Sensitization of melanoma cells for TRAIL-induced apoptosis by the potassium channel inhibitor TRAM-34 depends on release of SMACMechanism of the interaction between the intrinsically disordered C-terminus of the pro-apoptotic ARTS protein and the Bir3 domain of XIAPSynergistic effects of apigenin and paclitaxel on apoptosis of cancer cellsCritical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis
P2860
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P2860
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
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2000 nî lūn-bûn
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2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2000 թվականի օգոստոսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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Structural and biochemical basis of apoptotic activation by Smac/DIABLO
@ast
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
@en
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
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type
label
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
@ast
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
@en
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
@nl
prefLabel
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
@ast
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
@en
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
@nl
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P3181
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P1476
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
@en
P2093
P2888
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P3181
P356
10.1038/35022514
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P577
2000-08-24T00:00:00Z
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P6179
1051005104