How insulin engages its primary binding site on the insulin receptor
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In Memoriam: Guy Dodson (1937–2012)A brief history of macromolecular crystallography, illustrated by a family tree and its Nobel fruitsINS-gene mutations: from genetics and beta cell biology to clinical diseaseStructural Integrity of the B24 Site in Human Insulin Is Important for Hormone FunctionalityInsight into the Structural and Biological Relevance of the T/R Transition of the N-Terminus of the B-Chain in Human InsulinProtective hinge in insulin opens to enable its receptor engagementA minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulinIdentifying and Visualizing Macromolecular Flexibility in Structural BiologyRemembering donald f. SteinerStructural and functional study of the GlnB22-insulin mutant responsible for maturity-onset diabetes of the youngSite-specific covalent modifications of human insulin by catechol estrogens: Reactivity and induced structural and functional changesAromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.Contribution of TyrB26 to the Function and Stability of Insulin: STRUCTURE-ACTIVITY RELATIONSHIPS AT A CONSERVED HORMONE-RECEPTOR INTERFACE.Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.All-Atom Structural Models of the Transmembrane Domains of Insulin and Type 1 Insulin-Like Growth Factor ReceptorsInsulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation.YES, a Src family kinase, is a proximal glucose-specific activator of cell division cycle control protein 42 (Cdc42) in pancreatic islet β cellsMechanisms of activation of receptor tyrosine kinases: monomers or dimers.Insulin receptor activation with transmembrane domain ligands.Biophysical optimization of a therapeutic protein by nonstandard mutagenesis: studies of an iodo-insulin derivativeDeciphering a molecular mechanism of neonatal diabetes mellitus by the chemical synthesis of a protein diastereomer, [D-AlaB8]human proinsulin.Identification of a small molecular insulin receptor agonist with potent antidiabetes activity.Human GH receptor-IGF-1 receptor interaction: implications for GH signaling.Activation of transmembrane cell-surface receptors via a common mechanism? The "rotation model".Flexibility in the insulin receptor ectodomain enables docking of insulin in crystallographic conformation observed in a hormone-bound microreceptor.Donald F. Steiner MD, 1930-2014: discoverer of proinsulin.Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinityHow IGF-1 activates its receptor.Ligand regulation of a constitutively dimeric EGF receptor.Molecular Dynamics Simulations of Insulin: Elucidating the Conformational Changes that Enable Its BindingElucidating the Activation Mechanism of the Insulin-Family Proteins with Molecular Dynamics Simulations.Ligand-binding characteristics of feline insulin-binding immunoglobulin GThe insulin and IGF1 receptor kinase domains are functional dimers in the activated state.The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.Correlations Between Abnormal Glucose Metabolism and Bone Mineral Density or Bone MetabolismAchieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors.Diabetes mellitus due to the toxic misfolding of proinsulin variants.Association between markers of glucose metabolism and risk of colorectal cancer.Functional collaboration of insulin-like growth factor-1 receptor (IGF-1R), but not insulin receptor (IR), with acute GH signaling in mouse calvarial cells
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P2860
How insulin engages its primary binding site on the insulin receptor
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2013 nî lūn-bûn
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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
How insulin engages its primary binding site on the insulin receptor
@ast
How insulin engages its primary binding site on the insulin receptor
@en
How insulin engages its primary binding site on the insulin receptor
@nl
type
label
How insulin engages its primary binding site on the insulin receptor
@ast
How insulin engages its primary binding site on the insulin receptor
@en
How insulin engages its primary binding site on the insulin receptor
@nl
prefLabel
How insulin engages its primary binding site on the insulin receptor
@ast
How insulin engages its primary binding site on the insulin receptor
@en
How insulin engages its primary binding site on the insulin receptor
@nl
P2093
P2860
P50
P3181
P356
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P1476
How insulin engages its primary binding site on the insulin receptor
@en
P2093
Andrzej M Brzozowski
Christopher J Watson
Colin W Ward
Donald F Steiner
Emília Kletvíková
Geoffrey K-W Kong
Guy G Dodson
Jiří Jiráček
Jonathan Whittaker
Lenka Záková
P2860
P2888
P3181
P356
10.1038/NATURE11781
P407
P577
2013-01-10T00:00:00Z
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P6179
1022467752