Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues
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Landmarks in insulin researchHow insulin engages its primary binding site on the insulin receptorStructural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonistsNon-equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer InterfaceStructural Integrity of the B24 Site in Human Insulin Is Important for Hormone FunctionalityInsight into the Structural and Biological Relevance of the T/R Transition of the N-Terminus of the B-Chain in Human InsulinProtective hinge in insulin opens to enable its receptor engagementStructural and functional study of the GlnB22-insulin mutant responsible for maturity-onset diabetes of the youngContribution of TyrB26 to the Function and Stability of Insulin: STRUCTURE-ACTIVITY RELATIONSHIPS AT A CONSERVED HORMONE-RECEPTOR INTERFACE.Insulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation.Flexibility in the insulin receptor ectodomain enables docking of insulin in crystallographic conformation observed in a hormone-bound microreceptor.Molecular Dynamics Simulations of Insulin: Elucidating the Conformational Changes that Enable Its BindingInsulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform AThe insulin receptor: a new target for cancer therapy.Elucidating the Activation Mechanism of the Insulin-Family Proteins with Molecular Dynamics Simulations.The insulin receptor changes conformation in unforeseen ways on ligand binding: sharpening the picture of insulin receptor activation."Pruning of biomolecules and natural products (PBNP)": an innovative paradigm in drug discovery.Insulin mimetic peptide S371 folds into a helical structure.Biochemical contacts and collaborations between China and the U.K. since 1911.Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.Computational study of the activity, dynamics, energetics and conformations of insulin analogues using molecular dynamics simulations: Application to hyperinsulinemia and the critical residue B26.Rational steering of insulin binding specificity by intra-chain chemical crosslinkingHuman insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex.Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity.All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element.Identification of N-Terminally Truncated Derivatives of Insulin Analogs Formed in Pharmaceutical Formulations.A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding
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P2860
Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues
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2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Implications for the active fo ...... ighly active hormone analogues
@ast
Implications for the active fo ...... ighly active hormone analogues
@en
Implications for the active fo ...... ighly active hormone analogues
@nl
type
label
Implications for the active fo ...... ighly active hormone analogues
@ast
Implications for the active fo ...... ighly active hormone analogues
@en
Implications for the active fo ...... ighly active hormone analogues
@nl
prefLabel
Implications for the active fo ...... ighly active hormone analogues
@ast
Implications for the active fo ...... ighly active hormone analogues
@en
Implications for the active fo ...... ighly active hormone analogues
@nl
P2093
P2860
P3181
P356
P1476
Implications for the active fo ...... ighly active hormone analogues
@en
P2093
Andrzej M Brzozowski
Christopher J Watson
Emília Antolíková
Guy G Dodson
Jirí Jirácek
Lenka Záková
P2860
P304
P3181
P356
10.1073/PNAS.0911785107
P407
P577
2010-02-02T00:00:00Z