Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors
about
RNase H activity: structure, specificity, and function in reverse transcriptionSelective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolonesCatalytic mechanism of Escherichia coli ribonuclease III: kinetic and inhibitor evidence for the involvement of two magnesium ions in RNA phosphodiester hydrolysisMg2+ dependency of HIV-1 reverse transcription, inhibition by nucleoside analogues and resistance.Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active SiteStructural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H InhibitorsStructural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse TranscriptaseStructures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavagePurified Argonaute2 and an siRNA form recombinant human RISCHIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide SubstrateThe hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymesVirtual screening models for prediction of HIV-1 RT associated RNase H inhibitionInhibitor ranking through QM based chelation calculations for virtual screening of HIV-1 RNase H inhibitionMn2+ suppressor mutations and biochemical communication between Ty1 reverse transcriptase and RNase H domainsVinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activityNovel approaches to inhibiting HIV-1 replication.Evidence from molecular dynamics simulations of conformational preorganization in the ribonuclease H active site.Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.Hepatitis B virus replication is blocked by a 2-hydroxyisoquinoline-1,3(2H,4H)-dione (HID) inhibitor of the viral ribonuclease H activityStructure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors.Inhibitors of nucleotidyltransferase superfamily enzymes suppress herpes simplex virus replicationPhosphodiester cleavage in ribonuclease H occurs via an associative two-metal-aided catalytic mechanism.HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.Expression of an Mg2+-dependent HIV-1 RNase H construct for drug screeningThe hepatitis B virus ribonuclease H as a drug targetMutagenesis of human immunodeficiency virus reverse transcriptase p51 subunit defines residues contributing to vinylogous urea inhibition of ribonuclease H activity.Interaction of HIV-1 reverse transcriptase ribonuclease H with an acylhydrazone inhibitor.Inhibition of HIV-1 reverse transcription: basic principles of drug action and resistance.Protein-Inhibitor Interaction Studies Using NMRDiscovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1.Design, Synthesis, and Biological Evaluation of 1,2-Dihydroisoquinolines as HIV-1 Integrase Inhibitors.Free Energy-Based Virtual Screening and Optimization of RNase H Inhibitors of HIV-1 Reverse Transcriptase.Emerging reverse transcriptase inhibitors for the treatment of HIV infection in adults.Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity.3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations.Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H.Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase.Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity.
P2860
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P2860
Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Two-metal ion mechanism of RNA ...... lective HIV RNase H inhibitors
@ast
Two-metal ion mechanism of RNA ...... lective HIV RNase H inhibitors
@en
Two-metal ion mechanism of RNA ...... lective HIV RNase H inhibitors
@nl
type
label
Two-metal ion mechanism of RNA ...... lective HIV RNase H inhibitors
@ast
Two-metal ion mechanism of RNA ...... lective HIV RNase H inhibitors
@en
Two-metal ion mechanism of RNA ...... lective HIV RNase H inhibitors
@nl
prefLabel
Two-metal ion mechanism of RNA ...... lective HIV RNase H inhibitors
@ast
Two-metal ion mechanism of RNA ...... lective HIV RNase H inhibitors
@en
Two-metal ion mechanism of RNA ...... lective HIV RNase H inhibitors
@nl
P2093
P2860
P3181
P356
P1476
Two-metal ion mechanism of RNA ...... lective HIV RNase H inhibitors
@en
P2093
Andre Derosier
Hilary Overton
Joseph A Martin
Julie Qi Hang
Kevin E B Parkes
Klaus Klumpp
Nick Cammack
Philippe Wong Kai In
Surendran Rajendran
Yanli Yang
P2860
P304
P3181
P356
10.1093/NAR/GKG881
P407
P577
2003-12-01T00:00:00Z