Crystal structure of Escherichia coli RNase HI in complex with Mg2+ at 2.8 A resolution: proof for a single Mg(2+)-binding site
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Comparative sequence analysis of ribonucleases HII, III, II PH and DIdentification of catalytically relevant amino acids of the extracellular Serratia marcescens endonuclease by alignment-guided mutagenesisTwo-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitorsRNase H activity: structure, specificity, and function in reverse transcriptionRibonuclease H: properties, substrate specificity and roles in retroviral reverse transcriptionSubstrate-assisted catalysis: molecular basis and biological significanceCo-crystal of Escherichia coli RNase HI with Mn2+ ions reveals two divalent metals bound in the active siteDivalent metal cofactor binding in the kinetic folding trajectory ofEscherichia coliribonuclease HIStructure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active SitePurified Argonaute2 and an siRNA form recombinant human RISCA Computational Model for Predicting RNase H Domain of RetrovirusFunctional insight into Maelstrom in the germline piRNA pathway: a unique domain homologous to the DnaQ-H 3'-5' exonuclease, its lineage-specific expansion/loss and evolutionarily active site switch.Evidence from molecular dynamics simulations of conformational preorganization in the ribonuclease H active site.Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAsArgonautes confront new small RNAs.Identification of four acidic amino acids that constitute the catalytic center of the RuvC Holliday junction resolvase.Combining conformational flexibility and continuum electrostatics for calculating pK(a)s in proteins.Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the heteroduplex substrate.Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis.Substitution of a highly basic helix/loop sequence into the RNase H domain of human immunodeficiency virus reverse transcriptase restores its Mn(2+)-dependent RNase H activity.Ribonuclease H: molecular diversities, substrate binding domains, and catalytic mechanism of the prokaryotic enzymes.Crystal structure of the moloney murine leukemia virus RNase H domainDivalent metal ion-induced folding mechanism of RNase H1 from extreme halophilic archaeon Halobacterium sp. NRC-1.The rnhB gene encoding RNase HII of Streptococcus pneumoniae and evidence of conserved motifs in eucaryotic genes.RNAi: finding the elusive endonuclease.Structural basis for substrate recognition and processive cleavage mechanisms of the trimeric exonuclease PhoExo I.Ultradeep pyrosequencing and molecular modeling identify key structural features of hepatitis B virus RNase H, a putative target for antiviral interventionSpecificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase {alpha}4 helix.The role of template-primer in protection of reverse transcriptase from thermal inactivation.Role of metal ions in catalysis by HIV integrase analyzed using a quantitative PCR disintegration assay.Retroviral integrase, putting the pieces together.A dual role of divalent metal ions in catalysis and folding of RNase H1 from extreme halophilic archaeon Halobacterium sp. NRC-1.Catalytic residues in hydrolases: analysis of methods designed for ligand-binding site prediction.Side chain dynamics of carboxyl and carbonyl groups in the catalytic function of Escherichia coli ribonuclease H.Binding and cleavage specificities of human Argonaute2.Nucleotide docking: prediction of reactant state complexes for ribonuclease enzymes.Differential effects of Moloney murine leukemia virus reverse transcriptase mutations on RNase H activity in Mg2+ and Mn2+.Activation/attenuation model for RNase H. A one-metal mechanism with second-metal inhibition.Investigating the structure of human RNase H1 by site-directed mutagenesis.Roles of electrostatic interaction in proteins.
P2860
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P2860
Crystal structure of Escherichia coli RNase HI in complex with Mg2+ at 2.8 A resolution: proof for a single Mg(2+)-binding site
description
1993 nî lūn-bûn
@nan
1993 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Crystal structure of Escherich ...... r a single Mg(2+)-binding site
@ast
Crystal structure of Escherich ...... r a single Mg(2+)-binding site
@en
Crystal structure of Escherich ...... r a single Mg(2+)-binding site
@nl
type
label
Crystal structure of Escherich ...... r a single Mg(2+)-binding site
@ast
Crystal structure of Escherich ...... r a single Mg(2+)-binding site
@en
Crystal structure of Escherich ...... r a single Mg(2+)-binding site
@nl
prefLabel
Crystal structure of Escherich ...... r a single Mg(2+)-binding site
@ast
Crystal structure of Escherich ...... r a single Mg(2+)-binding site
@en
Crystal structure of Escherich ...... r a single Mg(2+)-binding site
@nl
P2093
P3181
P356
P1433
P1476
Crystal structure of Escherich ...... r a single Mg(2+)-binding site
@en
P2093
K Katayanagi
K Morikawa
P304
P3181
P356
10.1002/PROT.340170402
P407
P577
1993-12-01T00:00:00Z