Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects - Wikidata - wikimedia - TriplyDB

Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

http://www.wikidata.org/entity/Q24630458

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The plant-derived glucocorticoid receptor agonist Endiandrin A acts as co-stimulator of colonic epithelial sodium channels (ENaC) via SGK-1 and MAPKs Science review: mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids The use of inhaled corticosteroids in pediatric asthma: update Gene Expression Control by Glucocorticoid Receptors during Innate Immune Responses Emerging therapies for severe asthma MicroRNAs as tools to predict glucocorticoid response in inflammatory bowel diseases Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor Coupling of receptor conformation and ligand orientation determine graded activity Selective non-steroidal glucocorticoid receptor agonists attenuate inflammation but do not impair intestinal epithelial cell restitution in vitro Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index Evaluation of the selective glucocorticoid receptor agonist compound A for ototoxic effects Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.Investigation on critical structural motifs of ligands for triggering glucocorticoid receptor nuclear migration through molecular docking simulations.Palladium-catalyzed Csp(2)-H carbonylation of aromatic oximes: selective access to benzo[d][1,2]oxazin-1-ones and 3-methyleneisoindolin-1-ones.Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis.Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases Transrepression function of the glucocorticoid receptor regulates eyelid development and keratinocyte proliferation but is not sufficient to prevent skin chronic inflammation.Pharmacomimetics of exercise: novel approaches for hippocampally-targeted neuroprotective agents.Antiinflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor modulator in experimental autoimmune encephalomyelitis.Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound a.Ginsenoside Rh1 potentiates dexamethasone's anti-inflammatory effects for chronic inflammatory disease by reversing dexamethasone-induced resistance.Assessing the metabolic effects of prednisolone in healthy volunteers using urine metabolic profiling.11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity.Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties.Genomic and non-genomic actions of glucocorticoids in asthma A fully dissociated compound of plant origin for inflammatory gene repression Noncanonical mechanisms to regulate nuclear receptor signaling.LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.Glucocorticoid-targeted therapies for the treatment of rheumatoid arthritis.Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile.REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids How corticosteroids control inflammation: Quintiles Prize Lecture 2005 A complex task? Direct modulation of transcription factors with small molecules.Molecular mechanisms of glucocorticoids in the control of inflammation and lymphocyte apoptosis.The possible separation of 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation and hyperplasia by compound A.Safety and pharmacodynamic dose response of short-term prednisone in healthy adult subjects: a dose ranging, randomized, placebo-controlled, crossover study Rational and ethical use of topical corticosteroids based on safety and efficacy The molecular basis for the effectiveness, toxicity, and resistance to glucocorticoids: focus on the treatment of rheumatoid arthritis.

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Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

http://www.wikidata.org/entity/Q24630458

description

2004 nî lūn-bûn

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2004 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2004年の論文

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Dissociation of transactivatio ...... utic effects from side effects

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Dissociation of transactivatio ...... utic effects from side effects

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Dissociation of transactivatio ...... utic effects from side effects

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Dissociation of transactivatio ...... utic effects from side effects

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Dissociation of transactivatio ...... utic effects from side effects

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Dissociation of transactivatio ...... utic effects from side effects

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Dissociation of transactivatio ...... utic effects from side effects

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Proceedings of the National Academy of Sciences of the United States of America

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Dissociation of transactivatio ...... utic effects from side effects

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Arndt Schottelius

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Hartmut Rehwinkel

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Hartwig Hennekes

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Heike Schäcke

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Khusru Asadullah

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Norbert Schmees

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Peter Strehlke

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Stefan Jaroch

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Wolf-Dietrich Döcke

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P2860

Measurement of protein using bicinchoninic acid

An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile

Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation

Steroid hormone receptors: many actors in search of a plot

Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity.

Glucocorticoid signalling--multiple variations of a common theme.

Glucocorticoid-induced osteoporosis.

Molecular genetic analysis of glucocorticoid signaling using the Cre/loxP system.

A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects.

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227-32

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72513

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10.1073/PNAS.0300372101

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1

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101

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8943770

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14694204

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glucocorticoid receptor agonist

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314167

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