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Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

http://www.wikidata.org/entity/Q24630479

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CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.Regulation of mouse hepatic genes in response to diet induced obesity, insulin resistance and fasting induced weight reduction.Capping protein regulators fine-tune actin assembly dynamics The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85 Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85 Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl Ruk is ubiquitinated but not degraded by the proteasome The Cbl interactome and its functions Expression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface.SOX10 regulates expression of the SH3-domain kinase binding protein 1 (Sh3kbp1) locus in Schwann cells via an alternative promoter CIN85 interacting proteins in B cells-specific role for SHIP-1.ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking The interactome of a PTB domain-containing adapter protein, Odin, revealed by SILAC Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening.Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization CIN85/CMS family of adaptor molecules.Adaptor protein Ruk/CIN85 is associated with a subset of COPI-coated membranes of the Golgi complex.A draft of the human septin interactome.p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes.Phosphoinositide 3-kinase inhibition in cancer treatment.Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up.JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.Up-regulation of ALG-2 in hepatomas and lung cancer tissue.CD2AP regulates SUMOylation of CIN85 in podocytes.Cargo- and compartment-selective endocytic scaffold proteins.A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.

P2860

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P2860

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

http://www.wikidata.org/entity/Q24630479

description

2000 nî lūn-bûn

@nan

2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

@ast

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

@en

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

@nl

type

label

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

@ast

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

@en

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

@nl

prefLabel

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

@ast

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

@en

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

@nl

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P2860

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P1433

The EMBO Journal

P1476

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

@en

P2093

A M Davies

http://www.w3.org/2001/XMLSchema#string

G Matsuka

http://www.w3.org/2001/XMLSchema#string

G Middleton

http://www.w3.org/2001/XMLSchema#string

I Gout

http://www.w3.org/2001/XMLSchema#string

J Adu

http://www.w3.org/2001/XMLSchema#string

L B Drobot

http://www.w3.org/2001/XMLSchema#string

M Waterfield

http://www.w3.org/2001/XMLSchema#string

N N Ninkina

http://www.w3.org/2001/XMLSchema#string

V Filonenko

http://www.w3.org/2001/XMLSchema#string

V L Buchman

http://www.w3.org/2001/XMLSchema#string

P2860

CMS: an adapter molecule involved in cytoskeletal rearrangements

Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes

Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast.

The scanning model for translation: an update

Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p

Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains.

P304

4015-25

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/EMBOJ/19.15.4015

http://www.w3.org/2001/XMLSchema#string

P407

P433

15

http://www.w3.org/2001/XMLSchema#string

P478

19

http://www.w3.org/2001/XMLSchema#string

P577

2000-08-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

12397851

http://www.w3.org/2001/XMLSchema#string

P698

10921882

http://www.w3.org/2001/XMLSchema#string

P932

306608

http://www.w3.org/2001/XMLSchema#string