The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.
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Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbationsMisframed ubiquitin and impaired protein quality control: an early event in Alzheimer's diseaseCanine hereditary ataxia in old english sheepdogs and gordon setters is associated with a defect in the autophagy gene encoding RAB24Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegenerationSyntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturationThe Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's DiseaseNeuronal Mitophagy in Neurodegenerative DiseasesTau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.Differential transcriptome expression in human nucleus accumbens as a function of loneliness.Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling.Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L miceProtein homeostasis of a metastable subproteome associated with Alzheimer's disease.Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide in Alzheimer's diseaseProtein aggregation and degradation mechanisms in neurodegenerative diseasesHippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathologyDeciphering Alzheimer disease.Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease.Evaluation of the amyloid beta-GFP fusion protein as a model of amyloid beta peptides-mediated aggregation: a study of DNAJB6 chaperone.Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's diseaseAPP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology.Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease.Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice.Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid.Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.Selective worsening of brain injury biomarker abnormalities in cognitively normal elderly persons with β-amyloidosis.Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer's Disease.Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer's disease.IL-1β impairs retrograde flow of BDNF signaling by attenuating endosome traffickingNeurotoxicity of amyloid β-protein: synaptic and network dysfunction.Review: membrane-associated misfolded protein propagation in natural transmissible spongiform encephalopathies (TSEs), synthetic prion diseases and Alzheimer's disease.Emerging role of autophagy in pediatric neurodegenerative and neurometabolic diseases.Convergence of synapses, endosomes, and prions in the biology of neurodegenerative diseases.Autophagy coupling interplay: can improve cellular repair and aging?Aberrant expression of RCAN1 in Alzheimer's pathogenesis: a new molecular mechanism and a novel drug target.β-Amyloid peptides and amyloid plaques in Alzheimer's disease.The proteasome function reporter GFPu accumulates in young brains of the APPswe/PS1dE9 Alzheimer's disease mouse model.Synaptic activity protects against AD and FTD-like pathology via autophagic-lysosomal degradation.Exploring the power of yeast to model aging and age-related neurodegenerative disorders.Control of Amino Acid Homeostasis by a Ubiquitin Ligase-Coactivator Protein Complex.
P2860
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P2860
The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.
@ast
The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.
@en
type
label
The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.
@ast
The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.
@en
prefLabel
The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.
@ast
The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.
@en
P2093
P2860
P921
P1476
The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.
@en
P2093
Maho Morishima-Kawashima
Ralph Nixon
Yasuo Ihara
P2860
P356
10.1101/CSHPERSPECT.A006361
P577
2012-08-01T00:00:00Z