Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
about
Proteomic identification of Hsp70 as a new Plk1 substrate in arsenic trioxide-induced mitotically arrested cellsFrom an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemiaArsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathwayItraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonistsCarcinogenic effects of "whole-life" exposure to inorganic arsenic in CD1 miceThe hedgehog pathway in triple-negative breast cancerTargeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI InhibitorsHedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic SignalingThe Role of Hedgehog Signaling in Tumor Induced Bone DiseaseHedgehog Signaling in Malignant Pleural MesotheliomaCooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapyBasal cell carcinoma - molecular biology and potential new therapiesDarinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signalingFOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast CancerSurvival regulation of leukemia stem cellsArsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulationTRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress ResponseDYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistanceVMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells.Management of pediatric and adult patients with medulloblastoma.The role of GLI1 for 5-Fu resistance in colorectal cancerAdvanced treatment for basal cell carcinomas.Arsenic trioxide inhibits EBV reactivation and promotes cell death in EBV-positive lymphoma cells.Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.Arsenic: a potentially useful poison for Hedgehog-driven cancers.Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression.Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia.The hedgehog/Gli signaling paradigm in prostate cancerSynergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002.Neuropilins are positive regulators of Hedgehog signal transduction.Active site targeting of hedgehog precursor protein with phenylarsine oxide.Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia.Hedgehog pathway as a drug target: Smoothened inhibitors in development.Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical updateTargeting the Hedgehog signaling pathway in cancer: beyond Smoothened.Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis.Identification and functional characterization of novel transcriptional enhancers involved in regulating human GLI3 expression during early development.Molecular pathways: the hedgehog signaling pathway in cancer.Hedgehog pathway inhibition and the race against tumor evolution
P2860
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P2860
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector
@ast
Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector
@en
Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector
@nl
type
label
Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector
@ast
Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector
@en
Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector
@nl
prefLabel
Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector
@ast
Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector
@en
Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector
@nl
P2093
P2860
P3181
P356
P1476
Arsenic antagonizes the Hedgeh ...... Gli2 transcriptional effector
@en
P2093
Dale Gardner
John J Lee
Philip A Beachy
P2860
P304
P3181
P356
10.1073/PNAS.1006822107
P407
P577
2010-07-27T00:00:00Z