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Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

http://www.wikidata.org/entity/Q24632414

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Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells Biochemical effects of SIRT1 activators Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations Role of ROS and RNS Sources in Physiological and Pathological Conditions The Relationship between Metabolic Syndrome and Osteoporosis: A Review Metabolomics and Type 2 Diabetes: Translating Basic Research into Clinical Application HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis Acylcarnitines: reflecting or inflicting insulin resistance?Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor γ coactivator-1α Epigenomic elements analyses for promoters identify ESRRG as a new susceptibility gene for obesity-related traits Fructose consumption: recent results and their potential implications Sugar consumption, metabolic disease and obesity: The state of the controversy Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance Chaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance What is metabolic syndrome, and why are children getting it?Computational modeling and analysis of insulin induced eukaryotic translation initiation Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance Markers of skeletal muscle mitochondrial function and lipid accumulation are moderately associated with the homeostasis model assessment index of insulin resistance in obese men Metformin impairs mitochondrial function in skeletal muscle of both lean and diabetic rats in a dose-dependent manner Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573 Beneficial effects of omega-3 fatty acids on the consequences of a fructose diet are not mediated by PPAR delta or PGC1 alpha Activity-dependent repression of muscle genes by NFAT Mitochondrial Trifunctional Protein Defects: Clinical Implications and Therapeutic Approaches Nutritional approaches for managing obesity-associated metabolic diseases.Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway.Identification of Inhibitors of triacylglyceride accumulation in muscle cells: comparing HTS results from 1536-well plate-based and high-content platforms PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity.Ileal interposition surgery improves glucose and lipid metabolism and delays diabetes onset in the UCD-T2DM rat.Identification of direct and indirect social network effects in the pathophysiology of insulin resistance in obese human subjects Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype.MCM-test: a fuzzy-set-theory-based approach to differential analysis of gene pathways.Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity.Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance.Multiple abnormalities of myocardial insulin signaling in a porcine model of diet-induced obesity.Acyl-CoA synthesis, lipid metabolism and lipotoxicity.Diet-induced obesity prevents interstitial dispersion of insulin in skeletal muscle.

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Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

http://www.wikidata.org/entity/Q24632414

description

2006 nî lūn-bûn

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2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Molecular mechanisms of insuli ...... with mitochondrial dysfunction

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Molecular mechanisms of insuli ...... with mitochondrial dysfunction

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Molecular mechanisms of insuli ...... with mitochondrial dysfunction

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type

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Molecular mechanisms of insuli ...... with mitochondrial dysfunction

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Molecular mechanisms of insuli ...... with mitochondrial dysfunction

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Molecular mechanisms of insuli ...... with mitochondrial dysfunction

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Molecular mechanisms of insuli ...... with mitochondrial dysfunction

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Molecular mechanisms of insuli ...... with mitochondrial dysfunction

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Molecular mechanisms of insuli ...... with mitochondrial dysfunction

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Molecular mechanisms of insuli ...... with mitochondrial dysfunction

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Katsutaro Morino

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P2860

Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta

Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)

Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation.

Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents

Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases

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10.2337/DB06-S002

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5

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55 Suppl 2

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Gerald I. Shulman

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