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Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.

Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.

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Bacillus anthracis Inosine 5′-Monophosphate Dehydrogenase in Action: The First Bacterial Series of Structures of Phosphate Ion-, Substrate-, and Product-Bound Complexes De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans Structure ofPseudomonas aeruginosainosine 5′-monophosphate dehydrogenase The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents.Helicobacter pylori relies primarily on the purine salvage pathway for purine nucleotide biosynthesis A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity.Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis.The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α)(8) barrel enzymes.Inosine 5'-monophosphate dehydrogenase inhibitors as antimicrobial agents: recent progress and future perspectives.Inhibition of Inosine-5'-monophosphate Dehydrogenase from Bacillus anthracis: Mechanism Revealed by Pre-Steady-State Kinetics.A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open Access Malaria Box.

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P2860

Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.

http://www.wikidata.org/entity/Q30430133

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2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.

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Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.

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type

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Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.

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Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.

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prefLabel

Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.

@ast

Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.

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J.CHEMBIOL.2010.07.014

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Chemistry and Biology

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Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.

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Deviprasad R Gollapalli

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Iain S Macpherson

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Joanna B Goldberg

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Lizbeth Hedstrom

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Suresh Kumar Gorla

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The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase

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1084-1091

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scholarly article

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10.1016/J.CHEMBIOL.2010.07.014

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George W Liechti

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21035731

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