Concise total synthesis of (+/-)-salinosporamide A, (+/-)-cinnabaramide A, and derivatives via a bis-cyclization process: implications for a biosynthetic pathway?
about
Discovery and development of the anticancer agent salinosporamide A (NPI-0052).Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamidesSalinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.Sporolide B: Synthetic StudiesThe ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention.Asymmetric Synthesis of Deoxypropionate Derivatives via Catalytic Hydrogenolysis of Enantioenriched Z-Ketene HeterodimersA strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.Total synthesis of the unusual monoterpenoid indole alkaloid (±)-alstilobanine A.Total syntheses of the monoterpene indole alkaloids (±)-alstilobanine A and E and (±)-angustilodine.6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesisSynthesis and pharmacology of proteasome inhibitors.Recent progress towards transition metal-catalyzed synthesis of γ-lactams.Organocatalytic Lewis base functionalisation of carboxylic acids, esters and anhydrides via C1-ammonium or azolium enolates.Marinopyrroles: Unique Drug Discoveries Based on Marine Natural Products.Synthetic approaches towards alkaloids bearing α-tertiary amines.Synthesis of (±)-spongiolactone enabling discovery of a more potent derivative.Isothiourea-mediated one-pot synthesis of functionalized pyridines.Catalytic Asymmetric Synthesis of Ketene Heterodimer β-Lactones: Scope and Limitations.Bioinspired total synthesis and human proteasome inhibitory activity of (-)-salinosporamide A, (-)-homosalinosporamide A, and derivatives obtained via organonucleophile promoted bis-cyclizations.(S)-4-Trimethylsilyl-3-butyn-2-ol as an auxiliary for stereocontrolled synthesis of salinosporamide analogs with modifications at positions C2 and C5.A(1,3)-strain enabled retention of chirality during bis-cyclization of beta-ketoamides: total synthesis of (-)-salinosporamide A and (-)-homosalinosporamide A.Formal synthesis of salinosporamide A via NHC-catalyzed intramolecular lactonizationDouble diastereoselective, nucleophile-catalyzed aldol lactonizations (NCAL) leading to beta-lactone fused carbocycles and extensions to beta-lactone fused tetrahydrofuransEntry to heterocycles based on indium-catalyzed conia-ene reactions: asymmetric synthesis of (-)-salinosporamide A.Biomimetic Total Synthesis of (-)-Penibruguieramine A Using Memory of Chirality and Dynamic Kinetic Resolution.
P2860
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P2860
Concise total synthesis of (+/-)-salinosporamide A, (+/-)-cinnabaramide A, and derivatives via a bis-cyclization process: implications for a biosynthetic pathway?
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Concise total synthesis of (+/ ...... ns for a biosynthetic pathway?
@ast
Concise total synthesis of (+/ ...... ns for a biosynthetic pathway?
@en
Concise total synthesis of (+/ ...... ns for a biosynthetic pathway?
@nl
type
label
Concise total synthesis of (+/ ...... ns for a biosynthetic pathway?
@ast
Concise total synthesis of (+/ ...... ns for a biosynthetic pathway?
@en
Concise total synthesis of (+/ ...... ns for a biosynthetic pathway?
@nl
prefLabel
Concise total synthesis of (+/ ...... ns for a biosynthetic pathway?
@ast
Concise total synthesis of (+/ ...... ns for a biosynthetic pathway?
@en
Concise total synthesis of (+/ ...... ns for a biosynthetic pathway?
@nl
P2093
P2860
P356
P1433
P1476
Concise total synthesis of (+/ ...... ns for a biosynthetic pathway?
@en
P2093
P2860
P304
P356
10.1021/OL070616U
P407
P577
2007-05-24T00:00:00Z