Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.
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The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolutionSymplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca spConcise total synthesis of (+/-)-salinosporamide A, (+/-)-cinnabaramide A, and derivatives via a bis-cyclization process: implications for a biosynthetic pathway?Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropicaDiscovery and characterization of a marine bacterial SAM-dependent chlorinaseNext Generation Sequencing of Actinobacteria for the Discovery of Novel Natural ProductsNovel strategies to target the ubiquitin proteasome system in multiple myelomaMangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivityTargeted metagenomics as a tool to tap into marine natural product diversity for the discovery and production of drug candidatesThe 26S proteasome is a multifaceted target for anti-cancer therapiesSignal Transducers and Activators of Transcription (STAT) Regulatory Networks in Marine Organisms: From Physiological Observations towards Marine Drug DiscoveryDiversity of secondary metabolites from marine Bacillus species: chemistry and biological activityStructural Analysis of Spiro β-Lactone Proteasome InhibitorsSynthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibitionElucidation of the α-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibitionOmuralide and vibralactone: differences in the proteasome- β-lactone-γ-lactam binding scaffold alter target preferencesTrial Watch: Proteasomal inhibitors for anticancer therapyPathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathwaysMarine actinomycetes: a new source of compounds against the human malaria parasiteIdentification of Sare0718 as an alanine-activating adenylation domain in marine actinomycete Salinispora arenicola CNS-205A novel alkaloid from marine-derived actinomycete Streptomyces xinghaiensis with broad-spectrum antibacterial and cytotoxic activitiesMarine sediment-derived Streptomyces bacteria from British Columbia, Canada are a promising microbiota resource for the discovery of antimicrobial natural productsDiscovering the recondite secondary metabolome spectrum of Salinispora species: a study of inter-species diversityOceans and human health: Emerging public health risks in the marine environmentSpithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosusCulturable marine actinomycete diversity from tropical Pacific Ocean sediments.Culture-dependent and culture-independent diversity within the obligate marine actinomycete genus Salinispora.Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence.An N-acyl homolog of mycothiol is produced in marine actinomycetesTargeting the UPS as therapy in multiple myeloma.The UPS: a promising target for breast cancer treatment.Marinisporolides, polyene-polyol macrolides from a marine actinomycete of the new genus MarinisporaA tropical marine microbial natural products geobibliography as an example of desktop exploration of current research using web visualisation toolsIsolation, diversity, and antimicrobial activity of rare actinobacteria from medicinal plants of tropical rain forests in Xishuangbanna, China.Discovery and development of the anticancer agent salinosporamide A (NPI-0052).Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma.The ammosamides: structures of cell cycle modulators from a marine-derived Streptomyces species.Salinipyrones and pacificanones, mixed-precursor polyketides from the marine actinomycete Salinispora pacifica.Lodopyridone, a structurally unprecedented alkaloid from a marine actinomyceteThe marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp.
P2860
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P2860
Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.
description
2003 nî lūn-bûn
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2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
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2003年学术文章
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2003年学术文章
@zh-cn
2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年學術文章
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name
Salinosporamide A: a highly cy ...... of the new genus salinospora.
@ast
Salinosporamide A: a highly cy ...... of the new genus salinospora.
@en
type
label
Salinosporamide A: a highly cy ...... of the new genus salinospora.
@ast
Salinosporamide A: a highly cy ...... of the new genus salinospora.
@en
prefLabel
Salinosporamide A: a highly cy ...... of the new genus salinospora.
@ast
Salinosporamide A: a highly cy ...... of the new genus salinospora.
@en
P2093
P921
P356
P1476
Salinosporamide A: a highly cy ...... m of the new genus salinospora
@en
P2093
Christopher A Kauffman
Greg O Buchanan
Paul R Jensen
Robert H Feling
William Fenical
P304
P356
10.1002/ANIE.200390115
P407
P577
2003-01-01T00:00:00Z