Discovery and development of the anticancer agent salinosporamide A (NPI-0052). - Wikidata - wikimedia - TriplyDB

Discovery and development of the anticancer agent salinosporamide A (NPI-0052).

Discovery and development of the anticancer agent salinosporamide A (NPI-0052).

http://www.wikidata.org/entity/Q33622960

about

The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution Mangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivity Signal Transducers and Activators of Transcription (STAT) Regulatory Networks in Marine Organisms: From Physiological Observations towards Marine Drug Discovery Cnidarians as a source of new marine bioactive compounds--an overview of the last decade and future steps for bioprospecting The role of Snail in prostate cancer Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design Marine-Derived Pharmaceuticals - Challenges and Opportunities Marine sediment-derived Streptomyces bacteria from British Columbia, Canada are a promising microbiota resource for the discovery of antimicrobial natural products Discovering the recondite secondary metabolome spectrum of Salinispora species: a study of inter-species diversity Molecules to Ecosystems: Actinomycete Natural Products In situ Salinispora pacifica sp. nov., an actinomycete from marine sediments.Bioprospecting microbial natural product libraries from the marine environment for drug discovery.Proteasome inhibitors act as bifunctional antagonists of human immunodeficiency virus type 1 latency and replication.Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors Linking species concepts to natural product discovery in the post-genomic era Production of induced secondary metabolites by a co-culture of sponge-associated actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163.Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants Marine natural products: a new wave of drugs?Secondary metabolite gene expression and interplay of bacterial functions in a tropical freshwater cyanobacterial bloom.Diversity and distribution of the bioactive actinobacterial genus Salinispora from sponges along the Great Barrier Reef.Synthesis of a γ-lactam library via formal cycloaddition of imines and substituted succinic anhydrides.Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.Genetic complementation of the obligate marine actinobacterium Salinispora tropica with the large mechanosensitive channel gene mscL rescues cells from osmotic downshock.The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model Recent advances in proteasome inhibitor discovery.Synthesis of a library of "lead-like" γ-lactams by a one pot, four-component reaction Nitropyrrolins A-E, cytotoxic farnesyl-α-nitropyrroles from a marine-derived bacterium within the actinomycete family Streptomycetaceae Induction of apoptosis in cancer cell lines by the Red Sea brine pool bacterial extracts.Proteasome inhibitor patents (2010 - present).Co-cultivation--a powerful emerging tool for enhancing the chemical diversity of microorganisms Diversity and biotechnological potential of microorganisms associated with marine sponges.Evolution of secondary metabolite genes in three closely related marine actinomycete species α,β-Unsaturated carbonyl system of chalcone-based derivatives is responsible for broad inhibition of proteasomal activity and preferential killing of human papilloma virus (HPV) positive cervical cancer cells.Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species.Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation.Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives.Identification and bioactive potential of marine microorganisms from selected Florida coastal areas.

P2860

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P2860

Discovery and development of the anticancer agent salinosporamide A (NPI-0052).

http://www.wikidata.org/entity/Q33622960

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2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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Discovery and development of the anticancer agent salinosporamide A (NPI-0052).

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Discovery and development of the anticancer agent salinosporamide A (NPI-0052).

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Discovery and development of the anticancer agent salinosporamide A (NPI-0052).

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Discovery and development of the anticancer agent salinosporamide A (NPI-0052).

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Discovery and development of the anticancer agent salinosporamide A (NPI-0052).

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Discovery and development of the anticancer agent salinosporamide A (NPI-0052).

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J.BMC.2008.10.075

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Bioorganic & Medicinal Chemistry

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Discovery and development of the anticancer agent salinosporamide A (NPI-0052).

@en

P2093

Barbara C Potts

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G Kenneth Lloyd

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Kin S Lam

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Michael A Palladino

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Paul R Jensen

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William Fenical

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P2860

Concise total synthesis of (+/-)-salinosporamide A, (+/-)-cinnabaramide A, and derivatives via a bis-cyclization process: implications for a biosynthetic pathway?

Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution

Structure of 20S proteasome from yeast at 2.4 A resolution

The ubiquitin system

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

Salinispora arenicola gen. nov., sp. nov. and Salinispora tropica sp. nov., obligate marine actinomycetes belonging to the family Micromonosporaceae.

Bioactive microbial metabolites.

A phase 2 study of bortezomib in relapsed, refractory myeloma.

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