Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin
about
The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genesMbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains5-halogenated pyrimidine lesions within a CpG sequence context mimic 5-methylcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2).The current state of eukaryotic DNA base damage and repairTransition-state destabilization reveals how human DNA polymerase β proceeds across the chemically unstable lesion N7-methylguanineHuman alkyladenine DNA glycosylase employs a processive search for DNA damageTranscriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteinsA screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation.Transcriptional repressor domain of MBD1 is intrinsically disordered and interacts with its binding partners in a selective mannerA novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington diseaseAn invariant aspartic acid in the DNA glycosylase domain of DEMETER is necessary for transcriptional activation of the imprinted MEDEA gene.Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).DEMETER and REPRESSOR OF SILENCING 1 encode 5-methylcytosine DNA glycosylases.An epigenetic regulator: methyl-CpG-binding domain protein 1 (MBD1).N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents.A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.Base excision repair, aging and health span.DNA methylation and methyl-CpG binding proteins: developmental requirements and function.The role of methyl-binding proteins in chromatin organization and epigenome maintenance.Characterization of Dnmt3b:thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA.DNA methylation: dynamic and stable regulation of memory.Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway.Targeting polyamine metabolism for cancer therapy and prevention.The potential neuroprotection mechanism of GDNF in the 6-OHDA-induced cellular models of Parkinson's Disease.Acetylation- and Methylation-Related Epigenetic Proteins in the Context of Their Targets.Human AP endonuclease 1 stimulates multiple-turnover base excision by alkyladenine DNA glycosylaseEpigenetic modifications as novel therapeutic targets for Huntington's disease.Overlapping roles of the methylated DNA-binding protein MBD1 and polycomb group proteins in transcriptional repression of HOXA genes and heterochromatin foci formation.Epigenetics of Huntington's Disease.DNA Methylation and Adult Neurogenesis.
P2860
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P2860
Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Methylated DNA-binding domain ...... on and DNA repair in chromatin
@ast
Methylated DNA-binding domain ...... on and DNA repair in chromatin
@en
Methylated DNA-binding domain ...... on and DNA repair in chromatin
@nl
type
label
Methylated DNA-binding domain ...... on and DNA repair in chromatin
@ast
Methylated DNA-binding domain ...... on and DNA repair in chromatin
@en
Methylated DNA-binding domain ...... on and DNA repair in chromatin
@nl
prefLabel
Methylated DNA-binding domain ...... on and DNA repair in chromatin
@ast
Methylated DNA-binding domain ...... on and DNA repair in chromatin
@en
Methylated DNA-binding domain ...... on and DNA repair in chromatin
@nl
P2093
P2860
P356
P1476
Methylated DNA-binding domain ...... on and DNA repair in chromatin
@en
P2093
Masahiro Shirakawa
Michio Kawasuji
Mitsuyoshi Nakao
Naoyuki Fujita
Shu Tsuruzoe
Takaya Ichimura
P2860
P304
12859-12864
P356
10.1073/PNAS.2131819100
P407
P577
2003-10-10T00:00:00Z