Human AP endonuclease 1 stimulates multiple-turnover base excision by alkyladenine DNA glycosylase
about
Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sitesThe current state of eukaryotic DNA base damage and repairAn unprecedented nucleic acid capture mechanism for excision of DNA damageNon-productive DNA damage binding by DNA glycosylase-like protein Mag2 from Schizosaccharomyces pombeHopping enables a DNA repair glycosylase to search both strands and bypass a bound protein.AP-Endonuclease 1 Accelerates Turnover of Human 8-Oxoguanine DNA Glycosylase by Preventing Retrograde Binding to the Abasic-Site ProductHuman base excision repair creates a bias toward -1 frameshift mutationsNonspecific DNA binding and coordination of the first two steps of base excision repair.Recent advances in the structural mechanisms of DNA glycosylasesIdentification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitorsHighly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway.Substitution of active site tyrosines with tryptophan alters the free energy for nucleotide flipping by human alkyladenine DNA glycosylase.Kinetic mechanism for the excision of hypoxanthine by Escherichia coli AlkA and evidence for binding to DNA ends.Kinetic mechanism for the flipping and excision of 1,N(6)-ethenoadenine by AlkA.SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clampThe Inhibitory Effect of Non-Substrate and Substrate DNA on the Ligation and Self-Adenylylation Reactions Catalyzed by T4 DNA Ligase.Defining the functional footprint for recognition and repair of deaminated DNARepair of Alkylation Damage in Eukaryotic Chromatin Depends on Searching Ability of Alkyladenine DNA Glycosylase.Isolating contributions from intersegmental transfer to DNA searching by alkyladenine DNA glycosylase.Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.Transient-state kinetics of apurinic/apyrimidinic (AP) endonuclease 1 acting on an authentic AP site and commonly used substrate analogs: the effect of diverse metal ions and base mismatches.Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeastSmall-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs.The formation of catalytically competent enzyme-substrate complex is not a bottleneck in lesion excision by human alkyladenine DNA glycosylase.A chemical and kinetic perspective on base excision repair of DNA.Base excision repair enzymes protect abasic sites in duplex DNA from interstrand cross-linksAbundance of BER-related proteins depends on cell proliferation status and the presence of DNA polymerase β.Efficient recognition of an unpaired lesion by a DNA repair glycosylase.Kinetic mechanism for the flipping and excision of 1,N(6)-ethenoadenine by human alkyladenine DNA glycosylase.Slow repair of lipid peroxidation-induced DNA damage at p53 mutation hotspots in human cells caused by low turnover of a DNA glycosylaseSimultaneous sensitive detection of multiple DNA glycosylases from lung cancer cells at the single-molecule level.Kinetic Methods for Studying DNA Glycosylases Functioning in Base Excision Repair.
P2860
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P2860
Human AP endonuclease 1 stimulates multiple-turnover base excision by alkyladenine DNA glycosylase
description
2009 nî lūn-bûn
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2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
@zh-my
2009年学术文章
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2009年學術文章
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name
Human AP endonuclease 1 stimul ...... y alkyladenine DNA glycosylase
@en
Human AP endonuclease 1 stimul ...... y alkyladenine DNA glycosylase
@nl
type
label
Human AP endonuclease 1 stimul ...... y alkyladenine DNA glycosylase
@en
Human AP endonuclease 1 stimul ...... y alkyladenine DNA glycosylase
@nl
prefLabel
Human AP endonuclease 1 stimul ...... y alkyladenine DNA glycosylase
@en
Human AP endonuclease 1 stimul ...... y alkyladenine DNA glycosylase
@nl
P2860
P356
P1433
P1476
Human AP endonuclease 1 stimul ...... y alkyladenine DNA glycosylase
@en
P2093
Michael R Baldwin
Patrick J O'Brien
P2860
P304
P356
10.1021/BI900517Y
P407
P577
2009-06-01T00:00:00Z