Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption
about
Monoacylglycerol and diacylglycerol acyltransferases and the synthesis of neutral glycerides in Manduca sextaIntestinal triacylglycerol synthesis in fat absorption and systemic energy metabolismOver-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesityLipidomic and spatio-temporal imaging of fat by mass spectrometry in mice duodenum during lipid digestionModeling the mechanism of action of a DGAT1 inhibitor using a causal reasoning platformNocturnin regulates circadian trafficking of dietary lipid in intestinal enterocytes.Intestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial Triglycerides.Intestine-specific deletion of acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 protects mice from diet-induced obesity and glucose intolerance.Intestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity in Dgat1-/- miceHigh-content assays for evaluating cellular and hepatic diacylglycerol acyltransferase activity.Intestinal acyl-CoA:diacylglycerol acyltransferase 2 overexpression enhances postprandial triglyceridemic response and exacerbates high fat diet-induced hepatic triacylglycerol storageThe expression and regulation of enzymes mediating the biosynthesis of triglycerides and phospholipids in keratinocytes/epidermisEffect of the DGAT1 inhibitor pradigastat on triglyceride and apoB48 levels in patients with familial chylomicronemia syndromePhenotypic population screen identifies a new mutation in bovine DGAT1 responsible for unsaturated milk fatRole of the gut in modulating lipoprotein metabolism.The proteome of cytosolic lipid droplets isolated from differentiated Caco-2/TC7 enterocytes reveals cell-specific characteristicsIdentification of a botanical inhibitor of intestinal diacylglyceride acyltransferase 1 activity via in vitro screening and a parallel, randomized, blinded, placebo-controlled clinical trial.Gut triglyceride production.Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver.Acyl-CoA:Diacylglycerol Acyltransferase 1 Expression Level in the Hematopoietic Compartment Impacts Inflammation in the Vascular Plaques of Atherosclerotic Mice.Mechanism of hypertriglyceridemia in CTP:phosphoethanolamine cytidylyltransferase-deficient mice.Role of the gut in lipid homeostasisBeyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolismExposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane.Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight gain, hyperlipidemia, and hepatic steatosis in db/db mice.The modification of plant oil composition via metabolic engineering--better nutrition by design.Peripheral targets in obesity treatment: a comprehensive update.Therapeutic strategies for metabolic diseases: Small-molecule diacylglycerol acyltransferase (DGAT) inhibitors.Control of chylomicron export from the intestine.Infant digestion physiology and the relevance of in vitro biochemical models to test infant formula lipid digestion.Cell-based assay of MGAT2-driven diacylglycerol synthesis for profiling inhibitors: use of a stable isotope-labeled substrate and high-resolution LC/MS.Diacylglycerol acyltransferase-2 (DGAT2) and monoacylglycerol acyltransferase-2 (MGAT2) interact to promote triacylglycerol synthesisInvestigational therapies for hypercholesterolemia.Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, Manduca sexta.Congenital protein losing enteropathy: an inborn error of lipid metabolism due to DGAT1 mutations.Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseasesMOGAT2: A New Therapeutic Target for Metabolic Syndrome.Preclinical pharmacokinetic characterization of 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl) acetic acid, a novel DGAT-1 inhibitor.Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans.Pharmacological inhibition of diacylglycerol acyltransferase-1 and insights into postprandial gut peptide secretion.
P2860
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P2860
Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Acylation of acylglycerols by ...... the intestinal fat absorption
@ast
Acylation of acylglycerols by ...... the intestinal fat absorption
@en
Acylation of acylglycerols by ...... the intestinal fat absorption
@nl
type
label
Acylation of acylglycerols by ...... the intestinal fat absorption
@ast
Acylation of acylglycerols by ...... the intestinal fat absorption
@en
Acylation of acylglycerols by ...... the intestinal fat absorption
@nl
prefLabel
Acylation of acylglycerols by ...... the intestinal fat absorption
@ast
Acylation of acylglycerols by ...... the intestinal fat absorption
@en
Acylation of acylglycerols by ...... the intestinal fat absorption
@nl
P2093
P2860
P921
P3181
P356
P1476
Acylation of acylglycerols by ...... the intestinal fat absorption
@en
P2093
Anthony V Azzara
Ching-Hsuen Chu
Dong Cheng
Jahangir Iqbal
James Devenny
Jessica Dong
Luping Chen
M Mahmood Hussain
Mary Ann Pelleymounter
R Michael Lawrence
P2860
P304
P3181
P356
10.1074/JBC.M800494200
P407
P577
2008-10-31T00:00:00Z