Intestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity in Dgat1-/- mice
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Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolismIntestine-targeted DGAT1 inhibition improves obesity and insulin resistance without skin aberrations in miceDiacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in ratsModeling the mechanism of action of a DGAT1 inhibitor using a causal reasoning platformNocturnin regulates circadian trafficking of dietary lipid in intestinal enterocytes.Multimodal Nonlinear Optical Microscopy.Intestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial Triglycerides.Polydextrose changes the gut microbiome and attenuates fasting triglyceride and cholesterol levels in Western diet fed mice.Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscape.Shedding new light on lipid biology with coherent anti-Stokes Raman scattering microscopyCardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release.Intestinal acyl-CoA:diacylglycerol acyltransferase 2 overexpression enhances postprandial triglyceridemic response and exacerbates high fat diet-induced hepatic triacylglycerol storagePhenotypic population screen identifies a new mutation in bovine DGAT1 responsible for unsaturated milk fatDeficiency of MGAT2 increases energy expenditure without high-fat feeding and protects genetically obese mice from excessive weight gain.Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signalingLack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice.Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity.Identification of a botanical inhibitor of intestinal diacylglyceride acyltransferase 1 activity via in vitro screening and a parallel, randomized, blinded, placebo-controlled clinical trial.Acyl-CoA:Diacylglycerol Acyltransferase 1 Expression Level in the Hematopoietic Compartment Impacts Inflammation in the Vascular Plaques of Atherosclerotic Mice.Intestinal DGAT1 deficiency reduces postprandial triglyceride and retinyl ester excursions by inhibiting chylomicron secretion and delaying gastric emptying.Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorptionRole of the gut in lipid homeostasisIntestine-specific expression of MOGAT2 partially restores metabolic efficiency in Mogat2-deficient mice.Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.Dietary fat sensing via fatty acid oxidation in enterocytes: possible role in the control of eating.Gut-liver interaction in triglyceride-rich lipoprotein metabolism.Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia.Applications of coherent Raman scattering microscopies to clinical and biological studies.Control of chylomicron export from the intestine.Recent discoveries on absorption of dietary fat: Presence, synthesis, and metabolism of cytoplasmic lipid droplets within enterocytes.How lipid droplets "TAG" along: Glycerolipid synthetic enzymes and lipid storage.Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors.Reduced triglyceride secretion in response to an acute dietary fat challenge in obese compared to lean mice.Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans.Pharmacological inhibition of diacylglycerol acyltransferase-1 and insights into postprandial gut peptide secretion.Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action.Dgat1 and Dgat2 regulate enterocyte triacylglycerol distribution and alter proteins associated with cytoplasmic lipid droplets in response to dietary fat.The Role of Diacylglycerol Acyltransferase (DGAT) 1 and 2 in Cardiac Metabolism and Function.
P2860
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P2860
Intestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity in Dgat1-/- mice
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Intestine-specific expression ...... s and obesity in Dgat1-/- mice
@ast
Intestine-specific expression ...... s and obesity in Dgat1-/- mice
@en
type
label
Intestine-specific expression ...... s and obesity in Dgat1-/- mice
@ast
Intestine-specific expression ...... s and obesity in Dgat1-/- mice
@en
prefLabel
Intestine-specific expression ...... s and obesity in Dgat1-/- mice
@ast
Intestine-specific expression ...... s and obesity in Dgat1-/- mice
@en
P2093
P2860
P356
P1476
Intestine-specific expression ...... s and obesity in Dgat1-/- mice
@en
P2093
Angela M Fast
Bonggi Lee
Ji-Xin Cheng
Jiabin Zhu
Kimberly K Buhman
P2860
P304
P356
10.1194/JLR.M002311
P577
2010-02-10T00:00:00Z