about
Protein folding and quality control in the EREndoplasmic reticulum stress in the β-cell pathogenesis of type 2 diabetesSystematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cellsConcordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNASelective processing and metabolism of disease-causing mutant prion proteins.Cellular mechanisms of membrane protein folding.Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.Inefficient translocation of preproinsulin contributes to pancreatic β cell failure and late-onset diabetes.Transcriptome analysis and molecular signature of human retinal pigment epithelium.Control of precursor maturation and disposal is an early regulative mechanism in the normal insulin production of pancreatic β-cells.Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes.Substrate-favored lysosomal and proteasomal pathways participate in the normal balance control of insulin precursor maturation and disposal in β-cells.Differential age-dependent import regulation by signal peptides.Role of human sec63 in modulating the steady-state levels of multi-spanning membrane proteins.Effect of PKD1 gene missense mutations on polycystin-1 membrane topogenesis.Overexpression of human virus surface glycoprotein precursors induces cytosolic unfolded protein response in Saccharomyces cerevisiae.Prion protein biosynthesis and its emerging role in neurodegeneration.Characterization of early EDEM1 protein maturation events and their functional implications.Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex.Hypoxia elicits broad and systematic changes in protein subcellular localization.Sarcoglycanopathies: molecular pathogenesis and therapeutic prospectsLocal slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo.Modular assembly of synthetic proteins that span the plasma membrane in mammalian cellsEnhancement of the surface expression of G protein-coupled receptors.The GIP gamma-tubulin complex-associated proteins are involved in nuclear architecture in Arabidopsis thaliana.Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators.A ribosome-nascent chain sensor of membrane protein biogenesis in Bacillus subtilis.Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex.Low expression level of OB-Rb results from constitutive translocational attenuation attributable to a less efficient signal sequence.The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum.Mechanisms of cytosolic targeting of matrix metalloproteinase-2.Positional editing of transmembrane domains during ion channel assembly.Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria.Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum.alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulumThe cytosolic protein kinase CK2 phosphorylates cardiac calsequestrin in intact cells.Mammalian Prion protein expression in yeast; a model for transmembrane insertionHph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis.Sequential checkpoints govern substrate selection during cotranslational protein targeting.Ramanujan Hegde: The prion puzzle and protein translocation. Interview by Caitlin Sedwick.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The concept of translocational regulation
@ast
The concept of translocational regulation
@en
The concept of translocational regulation
@nl
type
label
The concept of translocational regulation
@ast
The concept of translocational regulation
@en
The concept of translocational regulation
@nl
prefLabel
The concept of translocational regulation
@ast
The concept of translocational regulation
@en
The concept of translocational regulation
@nl
P2860
P921
P356
P1476
The concept of translocational regulation
@en
P2093
Sang-Wook Kang
P2860
P304
P356
10.1083/JCB.200804157
P407
P577
2008-07-28T00:00:00Z