alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum

alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum

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http://www.wikidata.org/entity/Q39832083
Classification of intrinsically disordered regions and proteinsAnti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc)Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events.The most important thing is the tail: multitudinous functionalities of intrinsically disordered protein termini.The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum.Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria.The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication.The Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteins.Impaired transport of intrinsically disordered proteins through the Sec61 and SecY translocon; implications for prion diseases.Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum
P2860

alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum

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http://www.wikidata.org/entity/Q39832083
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alpha-Helical domains promote ...... into the endoplasmic reticulum
@en
alpha-Helical domains promote ...... nto the endoplasmic reticulum.
@nl
type
label
alpha-Helical domains promote ...... into the endoplasmic reticulum
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alpha-Helical domains promote ...... nto the endoplasmic reticulum.
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altLabel
α-Helical Domains Promote Tran ...... into the Endoplasmic Reticulum
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prefLabel
alpha-Helical domains promote ...... into the endoplasmic reticulum
@en
alpha-Helical domains promote ...... nto the endoplasmic reticulum.
@nl
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alpha-Helical domains promote ...... into the endoplasmic reticulum
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932