Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.
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Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAMDiscovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probeDiscovery of ML326: The first sub-micromolar, selective M5 PAMThe antipsychotic potential of muscarinic allosteric modulationControl of insulin secretion by cholinergic signaling in the human pancreatic islet.Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators.Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's DiseaseAllosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryCholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditionsStructural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists.Development of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficitsPractical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsM5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's locationEmerging approaches for treatment of schizophrenia: modulation of cholinergic signaling.Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators.Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs.Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule.Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetrationDiscovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe.Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe moleculeStructure-Activity Relationships of Pan-Gα Coupled Muscarinic Acetylcholine Receptor Positive Allosteric Modulators
P2860
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P2860
Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.
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2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Chemical lead optimization of ...... rst highly selective M(5) PAM.
@ast
Chemical lead optimization of ...... rst highly selective M(5) PAM.
@en
Chemical lead optimization of ...... rst highly selective M(5) PAM.
@nl
type
label
Chemical lead optimization of ...... rst highly selective M(5) PAM.
@ast
Chemical lead optimization of ...... rst highly selective M(5) PAM.
@en
Chemical lead optimization of ...... rst highly selective M(5) PAM.
@nl
prefLabel
Chemical lead optimization of ...... rst highly selective M(5) PAM.
@ast
Chemical lead optimization of ...... rst highly selective M(5) PAM.
@en
Chemical lead optimization of ...... rst highly selective M(5) PAM.
@nl
P2093
P2860
P50
P1476
Chemical lead optimization of ...... irst highly selective M(5) PAM
@en
P2093
Corey R Hopkins
Hyekyung P Cho
J Phillip Kennedy
Micah L Breininger
Thomas M Bridges
P2860
P304
P356
10.1016/J.BMCL.2009.11.089
P407
P577
2009-11-22T00:00:00Z