The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner - Wikidata - wikimedia - TriplyDB

The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner

The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner

http://www.wikidata.org/entity/Q33927277

about

AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex Targeting G protein coupled receptor-related pathways as emerging molecular therapies Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction Structure and dynamics of the M3 muscarinic acetylcholine receptor Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia Redundant catecholamine signaling consolidates fear memory via phospholipase C.A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairment M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1.Gene expression analysis following olfactory learning in Apis mellifera.Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain.Novel insights into the function of β-cell M3 muscarinic acetylcholine receptors: therapeutic implications.Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code.Inhibitory neuron and hippocampal circuit dysfunction in an aged mouse model of Alzheimer's disease.Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease.From Molecular Circuit Dysfunction to Disease: Case Studies in Epilepsy, Traumatic Brain Injury, and Alzheimer's Disease.Targeting chemokine receptors in disease--a case study of CCR4 Therapeutic potential of β-arrestin- and G protein-biased agonists.An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory.Employing novel animal models in the design of clinically efficacious GPCR ligands.Muscarinic acetylcholine receptors: novel opportunities for drug development.Insights into the structural biology of G-protein coupled receptors impacts drug design for central nervous system neurodegenerative processes.PACAP receptor pharmacology and agonist bias: analysis in primary neurons and glia from the trigeminal ganglia and transfected cells Neuromodulatory signaling in hippocampus-dependent memory retrieval.Cholinergic System and Post-translational Modifications: An Insight on the Role in Alzheimer's Disease Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research.Potential drug targets and treatment of schizophrenia.β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.Barcoding of GPCR trafficking and signaling through the various trafficking roadmaps by compartmentalized signaling networks.An experimental protocol for the fractionation and 2DE separation of HeLa and A-253 cell lysates suitable for the identification of the individual antigenic proteome in Sjögren's syndrome.Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL).The CHRM3 gene is implicated in abnormal thalamo-orbital frontal cortex functional connectivity in first-episode treatment-naive patients with schizophrenia.Diadenosine tetraphosphate contributes to carbachol-induced tear secretion.Deficit in learning and memory of rats with chronic fluorosis correlates with the decreased expressions of M1 and M3 muscarinic acetylcholine receptors.Muscarinic acetylcholine receptors act in synergy to facilitate learning and memory.Physiological roles of CNS muscarinic receptors gained from knockout mice.Biased signalling: from simple switches to allosteric microprocessors.M3 muscarinic receptor in the ventral medial prefrontal cortex modulating the expression of contextual fear conditioning in rats.Muscarinic receptor binding changes in postmortem Parkinson's disease.Pharmacological effects of Ibuprofen on learning and memory, muscarinic receptors gene expression and APP isoforms level in pre-frontal cortex of AlCl₃-induced toxicity mouse model.Functional Characterization of Acetylcholine Receptors Expressed in Human Neurons Differentiated from Hippocampal Neural Stem/Progenitor Cells.

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The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner

http://www.wikidata.org/entity/Q33927277

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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The M3-muscarinic receptor reg ...... tion/arrestin-dependent manner

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The M3-muscarinic receptor reg ...... tion/arrestin-dependent manner

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The M3-muscarinic receptor reg ...... tion/arrestin-dependent manner

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The M3-muscarinic receptor reg ...... tion/arrestin-dependent manner

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The M3-muscarinic receptor reg ...... tion/arrestin-dependent manner

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The M3-muscarinic receptor reg ...... tion/arrestin-dependent manner

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PNAS.0914801107

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Proceedings of the National Academy of Sciences of the United States of America

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The M3-muscarinic receptor reg ...... tion/arrestin-dependent manner

@en

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Adrian Butcher

http://www.w3.org/2001/XMLSchema#string

Andrew B Tobin

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Andrew Bottrill

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Benoit Poulin

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Elizabeth M Rosethorne

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Julie-Myrtille Bourgognon

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Jürgen Wess

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Kok Choi Kong

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Phillip McWilliams

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Robert Pawlak

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P2860

Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha

A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning

A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.

Effects of the selective M1 muscarinic receptor antagonist dicyclomine on emotional memory

Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean.

Current pharmacotherapy for Alzheimer's disease.

G protein-coupled receptors in major psychiatric disorders.

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9440-9445

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10.1073/PNAS.0914801107

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20

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107

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2010-05-03T00:00:00Z

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44570624

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20439723

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phosphorylation

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2889095

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